cytisine-2759 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the cytisine-2759 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ANG angiogenin, ribonuclease, RNase A family, 5
ANKMY1 ankyrin repeat and MYND domain containing 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARC activity-regulated cytoskeleton-associated protein
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATF7IP activating transcription factor 7 interacting protein
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BCR breakpoint cluster region
C19ORF73 chromosome 19 open reading frame 73
C1ORF56 chromosome 1 open reading frame 56
CACTIN cactin, spliceosome C complex subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD200 CD200 molecule
CD209 CD209 molecule
CGA glycoprotein hormones, alpha polypeptide
COL11A2 collagen, type XI, alpha 2
COL1A1 collagen, type I, alpha 1
COL7A1 collagen, type VII, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CRMP1 collapsin response mediator protein 1
CTSF cathepsin F
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
DOCK6 dedicator of cytokinesis 6
ENO3 enolase 3 (beta, muscle)
EVA1B eva-1 homolog B (C. elegans)
FGF5 fibroblast growth factor 5
FGFBP1 fibroblast growth factor binding protein 1
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
FSCN1 fascin actin-bundling protein 1
GAS6 growth arrest-specific 6
GPR1 G protein-coupled receptor 1
GRM7 glutamate receptor, metabotropic 7
HCRP1 hepatocellular carcinoma-related HCRP1
HIST1H3J histone cluster 1, H3j
HMGN5 high mobility group nucleosome binding domain 5
HOXA10 homeobox A10
IFI6 interferon, alpha-inducible protein 6
IL1B interleukin 1, beta
ING2 inhibitor of growth family, member 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KLK8 kallikrein-related peptidase 8
KRT17 keratin 17, type I
KRT19P2 keratin 19 pseudogene 2
LIMCH1 LIM and calponin homology domains 1
MAPK14 mitogen-activated protein kinase 14
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MORN1 MORN repeat containing 1
MRPL41 mitochondrial ribosomal protein L41
N4BP1 NEDD4 binding protein 1
NDRG2 NDRG family member 2
NKX3-2 NK3 homeobox 2
NPY4R neuropeptide Y receptor Y4
NRF1 nuclear respiratory factor 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEC plectin
PPP5C protein phosphatase 5, catalytic subunit
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PVR poliovirus receptor
QPCTL glutaminyl-peptide cyclotransferase-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS14 regulator of G-protein signaling 14
RPL10 ribosomal protein L10
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNDC3A RUN domain containing 3A
SARM1 sterile alpha and TIR motif containing 1
SCAPER S-phase cyclin A-associated protein in the ER
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SRSF5 serine/arginine-rich splicing factor 5
TAT tyrosine aminotransferase
TCF3 transcription factor 3
TEX40 testis expressed 40
TFF2 trefoil factor 2
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TMCC2 transmembrane and coiled-coil domain family 2
TMEM8B transmembrane protein 8B
TMLHE trimethyllysine hydroxylase, epsilon
TRAF2 TNF receptor-associated factor 2
TTC39A tetratricopeptide repeat domain 39A
UPK3B uroplakin 3B
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WDTC1 WD and tetratricopeptide repeats 1
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF493 zinc finger protein 493
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ADGRE5 adhesion G protein-coupled receptor E5
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALS2CL ALS2 C-terminal like
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARSB arylsulfatase B
BAHD1 bromo adjacent homology domain containing 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
C1ORF159 chromosome 1 open reading frame 159
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA5BP1 carbonic anhydrase VB pseudogene 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CLCN6 chloride channel, voltage-sensitive 6
CLDND1 claudin domain containing 1
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
FAM188A family with sequence similarity 188, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP5 FK506 binding protein 5
GAREM GRB2 associated, regulator of MAPK1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLS2 glutaminase 2 (liver, mitochondrial)
GSTCD glutathione S-transferase, C-terminal domain containing
HYI hydroxypyruvate isomerase (putative)
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL22 interleukin 22
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KDM5C lysine (K)-specific demethylase 5C
KIAA0894 KIAA0894 protein
KIF13B kinesin family member 13B
KRI1 KRI1 homolog (S. cerevisiae)
LMNB1 lamin B1
LRP3 low density lipoprotein receptor-related protein 3
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MCOLN1 mucolipin 1
MFAP2 microfibrillar-associated protein 2
MITF microphthalmia-associated transcription factor
MTCP1 mature T-cell proliferation 1
MXD3 MAX dimerization protein 3
NDE1 nudE neurodevelopment protein 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NPY5R neuropeptide Y receptor Y5
NUP62CL nucleoporin 62kDa C-terminal like
ONECUT2 one cut homeobox 2
OSMR oncostatin M receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PARD6A par-6 family cell polarity regulator alpha
PCDHA6 protocadherin alpha 6
PHACTR4 phosphatase and actin regulator 4
PLA2G3 phospholipase A2, group III
PLIN3 perilipin 3
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPL periplakin
PPOX protoporphyrinogen oxidase
PRICKLE3 prickle homolog 3 (Drosophila)
PROCR protein C receptor, endothelial
RAB30 RAB30, member RAS oncogene family
REEP4 receptor accessory protein 4
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
RPL10L ribosomal protein L10-like
SALL2 spalt-like transcription factor 2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC12A8 solute carrier family 12, member 8
SLC12A9 solute carrier family 12, member 9
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMAD7 SMAD family member 7
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STARD13 StAR-related lipid transfer (START) domain containing 13
STK16 serine/threonine kinase 16
TBC1D12 TBC1 domain family, member 12
TMEM62 transmembrane protein 62
TPCN1 two pore segment channel 1
TRAIP TRAF interacting protein
TUBGCP5 tubulin, gamma complex associated protein 5
TWISTNB TWIST neighbor
WDR25 WD repeat domain 25
WDR91 WD repeat domain 91
ZBTB22 zinc finger and BTB domain containing 22
ZNF211 zinc finger protein 211
ZNF324 zinc finger protein 324
ZNF394 zinc finger protein 394
ZNF668 zinc finger protein 668
ZSCAN31 zinc finger and SCAN domain containing 31