cytokine-mediated signaling pathway Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0019221)
External Link http://amigo.geneontology.org/amigo/term/GO_0019221
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Genes

258 genes participating in the cytokine-mediated signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
ACKR3 atypical chemokine receptor 3
ACTN4 actinin, alpha 4
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AIM2 absent in melanoma 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
APLP2 amyloid beta (A4) precursor-like protein 2
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
C1ORF186 chromosome 1 open reading frame 186
CARD14 caspase recruitment domain family, member 14
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL1 chemokine (C-C motif) ligand 1
CCL11 chemokine (C-C motif) ligand 11
CCL13 chemokine (C-C motif) ligand 13
CCL14 chemokine (C-C motif) ligand 14
CCL15 chemokine (C-C motif) ligand 15
CCL16 chemokine (C-C motif) ligand 16
CCL17 chemokine (C-C motif) ligand 17
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCL22 chemokine (C-C motif) ligand 22
CCL23 chemokine (C-C motif) ligand 23
CCL24 chemokine (C-C motif) ligand 24
CCL25 chemokine (C-C motif) ligand 25
CCL26 chemokine (C-C motif) ligand 26
CCL3 chemokine (C-C motif) ligand 3
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL4 chemokine (C-C motif) ligand 4
CCL4L1 chemokine (C-C motif) ligand 4-like 1
CCL5 chemokine (C-C motif) ligand 5
CCL7 chemokine (C-C motif) ligand 7
CCL8 chemokine (C-C motif) ligand 8
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CD300LF CD300 molecule-like family member f
CD4 CD4 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHUK conserved helix-loop-helix ubiquitous kinase
CLCF1 cardiotrophin-like cytokine factor 1
CNTF ciliary neurotrophic factor
CNTFR ciliary neurotrophic factor receptor
COMMD7 COMM domain containing 7
CRLF1 cytokine receptor-like factor 1
CRLF2 cytokine receptor-like factor 2
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSNK2B casein kinase 2, beta polypeptide
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSG cathepsin G
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR2 chemokine (C-X-C motif) receptor 2
DUOX1 dual oxidase 1
DUOX2 dual oxidase 2
EBI3 Epstein-Barr virus induced 3
EDN2 endothelin 2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPO erythropoietin
EPOR erythropoietin receptor
EREG epiregulin
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FER fer (fps/fes related) tyrosine kinase
FLT3 fms-related tyrosine kinase 3
FOXC1 forkhead box C1
FOXO3 forkhead box O3
GHR growth hormone receptor
GPR35 G protein-coupled receptor 35
GPR75 G protein-coupled receptor 75
GREM2 gremlin 2, DAN family BMP antagonist
HCK HCK proto-oncogene, Src family tyrosine kinase
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNK interferon, kappa
IFNW1 interferon, omega 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL11 interleukin 11
IL11RA interleukin 11 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL17RC interleukin 17 receptor C
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL1R1 interleukin 1 receptor, type I
IL1RAP interleukin 1 receptor accessory protein
IL2 interleukin 2
IL21R interleukin 21 receptor
IL23R interleukin 23 receptor
IL27RA interleukin 27 receptor, alpha
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL3 interleukin 3
IL31RA interleukin 31 receptor A
IL33 interleukin 33
IL33R interleukin 33 receptor
IL34 interleukin 34
IL36A interleukin 36, alpha
IL36B interleukin 36, beta
IL36G interleukin 36, gamma
IL37 interleukin 37
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
IL9R interleukin 9 receptor
ILK integrin-linked kinase
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
JAGN1 jagunal homolog 1 (Drosophila)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LEP leptin
LEPR leptin receptor
LIFR leukemia inhibitory factor receptor alpha
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2
LIMS1 LIM and senescent cell antigen-like domains 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK3 mitogen-activated protein kinase 3
MFAP3 microfibrillar-associated protein 3
MT3 metallothionein 3
MX1 MX dynamin-like GTPase 1
MYD88 myeloid differentiation primary response 88
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUMBL numb homolog (Drosophila)-like
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OASL 2'-5'-oligoadenylate synthetase-like
OSM oncostatin M
OSMR oncostatin M receptor
P4HB prolyl 4-hydroxylase, beta polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PF4 platelet factor 4
PF4V1 platelet factor 4 variant 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PLVAP plasmalemma vesicle associated protein
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRLR prolactin receptor
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRJ protein tyrosine phosphatase, receptor type, J
PYCARD PYD and CARD domain containing
PYDC1 PYD (pyrin domain) containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRAGA Ras-related GTP binding A
SIRT1 sirtuin 1
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SMAD4 SMAD family member 4
SOCS1 suppressor of cytokine signaling 1
SOCS5 suppressor of cytokine signaling 5
SOS1 son of sevenless homolog 1 (Drosophila)
SPI1 Spi-1 proto-oncogene
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST18 suppression of tumorigenicity 18, zinc finger
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TFF2 trefoil factor 2
TMSB4X thymosin beta 4, X-linked
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNIP2 TNFAIP3 interacting protein 2
TOLLIP toll interacting protein
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF3IP2 TRAF3 interacting protein 2
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TXNDC17 thioredoxin domain containing 17
TYK2 tyrosine kinase 2
UGCG UDP-glucose ceramide glucosyltransferase
XCL1 chemokine (C motif) ligand 1
XCL2 chemokine (C motif) ligand 2
YAP1 Yes-associated protein 1
ZNF675 zinc finger protein 675