cytolytic granule Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. (Gene Ontology, GO_0044194)
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68 proteins co-occuring with the cytolytic granule cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PRF1 perforin 1 (pore forming protein) 2.38859
GNLY granulysin 2.03941
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.74701
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 1.68971
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 1.53331
RNF19B ring finger protein 19B 1.09289
CD226 CD226 molecule 0.996613
FASLG Fas ligand (TNF superfamily, member 6) 0.948284
GZMM granzyme M (lymphocyte met-ase 1) 0.851583
GZMK granzyme K (granzyme 3; tryptase II) 0.80523
NCR1 natural cytotoxicity triggering receptor 1 0.783241
CD4 CD4 molecule 0.754983
IL2 interleukin 2 0.747285
NCAM1 neural cell adhesion molecule 1 0.733319
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.707039
UNC13D unc-13 homolog D (C. elegans) 0.706598
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.693832
CCDC130 coiled-coil domain containing 130 0.676368
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.668559
GLIS2 GLIS family zinc finger 2 0.656464
DOCK8 dedicator of cytokinesis 8 0.630318
LAMP1 lysosomal-associated membrane protein 1 0.609086
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.565923
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.525931
UCKL1 uridine-cytidine kinase 1-like 1 0.517756
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.49661
ICAM1 intercellular adhesion molecule 1 0.468001
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.462398
RAB27A RAB27A, member RAS oncogene family 0.461199
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.458006
CORO1C coronin, actin binding protein, 1C 0.446465
CD244 CD244 molecule, natural killer cell receptor 2B4 0.431041
CXCR3 chemokine (C-X-C motif) receptor 3 0.418468
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.393549
SVIL supervillin 0.384665
CD27 CD27 molecule 0.370833
CD8A CD8a molecule 0.364713
EOMES eomesodermin 0.361277
ETV3 ets variant 3 0.359752
CAMP cathelicidin antimicrobial peptide 0.35899
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.358609
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.356705
KSR1 kinase suppressor of ras 1 0.331719
CCL5 chemokine (C-C motif) ligand 5 0.329084
CD58 CD58 molecule 0.325327
CTSC cathepsin C 0.304771
CD200 CD200 molecule 0.291787
CMA1 chymase 1, mast cell 0.27998
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 0.278509
CD19 CD19 molecule 0.275202
CXCL11 chemokine (C-X-C motif) ligand 11 0.266042
CD80 CD80 molecule 0.264946
CORO1A coronin, actin binding protein, 1A 0.261296
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.257289
RAB27B RAB27B, member RAS oncogene family 0.240276
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.224913
WASH7P WAS protein family homolog 7 pseudogene 0.220321
WASH6P WAS protein family homolog 6 pseudogene 0.21716
ITK IL2-inducible T-cell kinase 0.216111
WASH1 WAS protein family homolog 1 0.215063
CCL3 chemokine (C-C motif) ligand 3 0.194371
HLA-E major histocompatibility complex, class I, E 0.194045
ICAM2 intercellular adhesion molecule 2 0.178588
UNC13B unc-13 homolog B (C. elegans) 0.175188
DMPK dystrophia myotonica-protein kinase 0.165231
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.162546
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.157943
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.157218