cytotoxicity Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

407 genes co-occuring with the biological term cytotoxicity in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACBD3 acyl-CoA binding domain containing 3
ACER2 alkaline ceramidase 2
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANTXR2 anthrax toxin receptor 2
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ARL8B ADP-ribosylation factor-like 8B
AS3MT arsenite methyltransferase
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATXN3 ataxin 3
AURKA aurora kinase A
B2M beta-2-microglobulin
B3GAT1 beta-1,3-glucuronyltransferase 1
BAD BCL2-associated agonist of cell death
BAG6 BCL2-associated athanogene 6
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC5 baculoviral IAP repeat containing 5
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
C9 complement component 9
CADM1 cell adhesion molecule 1
CALB2 calbindin 2
CANX calnexin
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCND1 cyclin D1
CD19 CD19 molecule
CD1C CD1c molecule
CD1D CD1d molecule
CD226 CD226 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD33 CD33 molecule
CD37 CD37 molecule
CD38 CD38 molecule
CD4 CD4 molecule
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CD48 CD48 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD69 CD69 molecule
CD86 CD86 molecule
CD96 CD96 molecule
CDC20 cell division cycle 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFH complement factor H
CFL1 cofilin 1 (non-muscle)
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CLDN14 claudin 14
CLDN4 claudin 4
CLDN8 claudin 8
CLEC2D C-type lectin domain family 2, member D
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRP C-reactive protein, pentraxin-related
CRTAM cytotoxic and regulatory T cell molecule
CRYAA crystallin, alpha A
CRYAB crystallin, alpha B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSE cathepsin E
CTSW cathepsin W
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CYCS cytochrome c, somatic
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCPS decapping enzyme, scavenger
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFB103B defensin, beta 103B
DGUOK deoxyguanosine kinase
DIABLO diablo, IAP-binding mitochondrial protein
DNASE1L3 deoxyribonuclease I-like 3
DNM2 dynamin 2
DOCK8 dedicator of cytokinesis 8
DRD1 dopamine receptor D1
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
DYNLL1 dynein, light chain, LC8-type 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
ENDOG endonuclease G
ENO1 enolase 1, (alpha)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
EXO1 exonuclease 1
EXOSC5 exosome component 5
FASLG Fas ligand (TNF superfamily, member 6)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FERMT3 fermitin family member 3
FOXM1 forkhead box M1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GJB1 gap junction protein, beta 1, 32kDa
GLRX glutaredoxin (thioltransferase)
GSTM1 glutathione S-transferase mu 1
GTSE1 G-2 and S-phase expressed 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMK granzyme K (granzyme 3; tryptase II)
HAVCR2 hepatitis A virus cellular receptor 2
HFE hemochromatosis
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMBOX1 homeobox containing 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA9 heat shock 70kDa protein 9 (mortalin)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTRA1 HtrA serine peptidase 1
HTRA3 HtrA serine peptidase 3
HTT huntingtin
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFNA1 interferon, alpha 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGFBP3 insulin-like growth factor binding protein 3
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IHH indian hedgehog
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL12A interleukin 12A
IL12B interleukin 12B
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL21 interleukin 21
IL22 interleukin 22
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK2 Janus kinase 2
JAKMIP1 janus kinase and microtubule interacting protein 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIF7 kinesin family member 7
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KLRC2 killer cell lectin-like receptor subfamily C, member 2
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRF1 killer cell lectin-like receptor subfamily F, member 1
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KMT2E lysine (K)-specific methyltransferase 2E
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMP1 lysosomal-associated membrane protein 1
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS9 lectin, galactoside-binding, soluble, 9
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LONP1 lon peptidase 1, mitochondrial
LRP2 low density lipoprotein receptor-related protein 2
LYST lysosomal trafficking regulator
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIP major intrinsic protein of lens fiber
MIR21 microRNA 21
MIR27A microRNA 27a
MIR449A microRNA 449a
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MT2A metallothionein 2A
MT3 metallothionein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NAMPT nicotinamide phosphoribosyltransferase
NAPRT nicotinate phosphoribosyltransferase
NCAM1 neural cell adhesion molecule 1
NCR1 natural cytotoxicity triggering receptor 1
NCR2 natural cytotoxicity triggering receptor 2
NCR3 natural cytotoxicity triggering receptor 3
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP3 NLR family, pyrin domain containing 3
NOTCH1 notch 1
NOX4 NADPH oxidase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5C1A 5'-nucleotidase, cytosolic IA
ORAI1 ORAI calcium release-activated calcium modulator 1
PARP1 poly (ADP-ribose) polymerase 1
PDCD1 programmed cell death 1
PDGFB platelet-derived growth factor beta polypeptide
PGK1 phosphoglycerate kinase 1
PHB prohibitin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PML promyelocytic leukemia
PNLIPRP2 pancreatic lipase-related protein 2
POLK polymerase (DNA directed) kappa
POU2F1 POU class 2 homeobox 1
PPID peptidylprolyl isomerase D
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRF1 perforin 1 (pore forming protein)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCZ protein kinase C, zeta
PRND prion protein 2 (dublet)
PRNP prion protein
PSEN1 presenilin 1
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTMA prothymosin, alpha
PTOV1 prostate tumor overexpressed 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PVR poliovirus receptor
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PYCARD PYD and CARD domain containing
RAB11A RAB11A, member RAS oncogene family
RAET1E retinoic acid early transcript 1E
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RALBP1 ralA binding protein 1
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBP3 retinol binding protein 3, interstitial
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REPS1 RALBP1 associated Eps domain containing 1
RHOF ras homolog family member F (in filopodia)
RHOG ras homolog family member G
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPSA ribosomal protein SA
RRM2 ribonucleotide reductase M2
RUNX3 runt-related transcription factor 3
RXRA retinoid X receptor, alpha
S100A11 S100 calcium binding protein A11
SCARB1 scavenger receptor class B, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SET SET nuclear proto-oncogene
SFTPC surfactant protein C
SH2D1A SH2 domain containing 1A
SH2D1B SH2 domain containing 1B
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC9 sialic acid binding Ig-like lectin 9
SIRT1 sirtuin 1
SIRT4 sirtuin 4
SLAMF6 SLAM family member 6
SLAMF7 SLAM family member 7
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPK1 SRSF protein kinase 1
SSB Sjogren syndrome antigen B (autoantigen La)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STK4 serine/threonine kinase 4
STX11 syntaxin 11
STXBP2 syntaxin binding protein 2
SUMO1 small ubiquitin-like modifier 1
TAC1 tachykinin, precursor 1
TALDO1 transaldolase 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TARDBP TAR DNA binding protein
TBX21 T-box 21
TERT telomerase reverse transcriptase
TFR2 transferrin receptor 2
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIGIT T cell immunoreceptor with Ig and ITIM domains
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMSB4Y thymosin beta 4, Y-linked
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TOLLIP toll interacting protein
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TPMT thiopurine S-methyltransferase
TRIP10 thyroid hormone receptor interactor 10
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TTR transthyretin
TXN thioredoxin
TYROBP TYRO protein tyrosine kinase binding protein
UBE2M ubiquitin-conjugating enzyme E2M
ULBP1 UL16 binding protein 1
ULBP3 UL16 binding protein 3
UPP1 uridine phosphorylase 1
VAV1 vav 1 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VSNL1 visinin-like 1
WAS Wiskott-Aldrich syndrome
WRN Werner syndrome, RecQ helicase-like
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF521 zinc finger protein 521
ZYX zyxin