dacarbazine-4480 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the dacarbazine-4480 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAP1 ArfGAP with dual PH domains 1
ADCY1 adenylate cyclase 1 (brain)
AKAP5 A kinase (PRKA) anchor protein 5
ALPK3 alpha-kinase 3
AMH anti-Mullerian hormone
ANP32A-IT1 ANP32A intronic transcript 1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC4 armadillo repeat containing 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATM ATM serine/threonine kinase
BAAT bile acid CoA:amino acid N-acyltransferase
BMP10 bone morphogenetic protein 10
C22ORF46 chromosome 22 open reading frame 46
CDK13 cyclin-dependent kinase 13
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L2 chitinase 3-like 2
CLCA1 chloride channel accessory 1
CLEC3B C-type lectin domain family 3, member B
CLSTN3 calsyntenin 3
CLTCL1 clathrin, heavy chain-like 1
COL5A1 collagen, type V, alpha 1
CREB3L1 cAMP responsive element binding protein 3-like 1
DCTN1 dynactin 1
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
EDAR ectodysplasin A receptor
ETNK2 ethanolamine kinase 2
FBXO11 F-box protein 11
FLJ42627 uncharacterized LOC645644
FUBP1 far upstream element (FUSE) binding protein 1
FUT2 fucosyltransferase 2 (secretor status included)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L galactosidase, beta 1-like
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM7 glutamate receptor, metabotropic 7
HHAT hedgehog acyltransferase
HOXD1 homeobox D1
HPX hemopexin
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPG2 heparan sulfate proteoglycan 2
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICA1 islet cell autoantigen 1, 69kDa
ID2B inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein (pseudogene)
IL36RN interleukin 36 receptor antagonist
KCNIP1 Kv channel interacting protein 1
KIAA0319L KIAA0319-like
KIAA0391 KIAA0391
KIAA1107 KIAA1107
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KISS1 KiSS-1 metastasis-suppressor
KLF6 Kruppel-like factor 6
LAPTM5 lysosomal protein transmembrane 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LOC100294391 uncharacterized LOC100294391
LOC157562 uncharacterized LOC157562
LRRC37A3 leucine rich repeat containing 37, member A3
MAN1C1 mannosidase, alpha, class 1C, member 1
MAST2 microtubule associated serine/threonine kinase 2
MCF2L MCF.2 cell line derived transforming sequence-like
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MNMIP1 manchette microtubule inner protein 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLIN2 perilipin 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PQBP1 polyglutamine binding protein 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRH protein tyrosine phosphatase, receptor type, H
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRU protein tyrosine phosphatase, receptor type, U
RBM48 RNA binding motif protein 48
REC8 REC8 meiotic recombination protein
ROM1 retinal outer segment membrane protein 1
RPH3A rabphilin 3A
RUNDC3B RUN domain containing 3B
SERHL2 serine hydrolase-like 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIM2 single-minded family bHLH transcription factor 2
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SMAD1 SMAD family member 1
SOX15 SRY (sex determining region Y)-box 15
SYCE1L synaptonemal complex central element protein 1-like
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TOR4A torsin family 4, member A
TRPM3 transient receptor potential cation channel, subfamily M, member 3
XAF1 XIAP associated factor 1
YIPF2 Yip1 domain family, member 2
YIPF4 Yip1 domain family, member 4

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATG10 autophagy related 10
BBC3 BCL2 binding component 3
BEX1 brain expressed, X-linked 1
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C14ORF93 chromosome 14 open reading frame 93
CD70 CD70 molecule
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDK6 cyclin-dependent kinase 6
CES3 carboxylesterase 3
CISH cytokine inducible SH2-containing protein
CLCN6 chloride channel, voltage-sensitive 6
CLDN1 claudin 1
CNGB3 cyclic nucleotide gated channel beta 3
COBL cordon-bleu WH2 repeat protein
CYB5R2 cytochrome b5 reductase 2
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
EDIL3 EGF-like repeats and discoidin I-like domains 3
EIF5A2 eukaryotic translation initiation factor 5A2
ELMO3 engulfment and cell motility 3
EXD3 exonuclease 3'-5' domain containing 3
FBXL15 F-box and leucine-rich repeat protein 15
FBXO2 F-box protein 2
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
FOXN2 forkhead box N2
FUZ fuzzy planar cell polarity protein
GAL3ST4 galactose-3-O-sulfotransferase 4
GDAP2 ganglioside induced differentiation associated protein 2
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GTF2I general transcription factor IIi
HIST1H1D histone cluster 1, H1d
HIST1H1T histone cluster 1, H1t
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BM histone cluster 1, H2bm
HIST1H3B histone cluster 1, H3b
HIST1H3C histone cluster 1, H3c
HIST1H4D histone cluster 1, H4d
HIST1H4E histone cluster 1, H4e
HOXA2 homeobox A2
HOXC10 homeobox C10
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFI6 interferon, alpha-inducible protein 6
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL33 interleukin 33
ISYNA1 inositol-3-phosphate synthase 1
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT31 keratin 31, type I
LIN7B lin-7 homolog B (C. elegans)
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LTC4S leukotriene C4 synthase
LY86 lymphocyte antigen 86
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAGEF1 melanoma antigen family F1
MCC mutated in colorectal cancers
MFAP2 microfibrillar-associated protein 2
MFSD6 major facilitator superfamily domain containing 6
MYOZ3 myozenin 3
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OSMR oncostatin M receptor
PARP6 poly (ADP-ribose) polymerase family, member 6
PCDHA9 protocadherin alpha 9
PDE12 phosphodiesterase 12
PICK1 protein interacting with PRKCA 1
PID1 phosphotyrosine interaction domain containing 1
PRF1 perforin 1 (pore forming protein)
RASA2 RAS p21 protein activator 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SLC12A8 solute carrier family 12, member 8
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMR3A submaxillary gland androgen regulated protein 3A
SPTBN2 spectrin, beta, non-erythrocytic 2
STON1 stonin 1
SYNC syncoilin, intermediate filament protein
TEX15 testis expressed 15
TIGD6 tigger transposable element derived 6
TM6SF1 transmembrane 6 superfamily member 1
TMEM209 transmembrane protein 209
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
ZNF428 zinc finger protein 428