dantrolene-2329 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the dantrolene-2329 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAM19 ADAM metallopeptidase domain 19
ADAM23 ADAM metallopeptidase domain 23
ADD2 adducin 2 (beta)
AHNAK2 AHNAK nucleoprotein 2
ALDOB aldolase B, fructose-bisphosphate
BCAN brevican
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BIN1 bridging integrator 1
C17ORF59 chromosome 17 open reading frame 59
C19ORF66 chromosome 19 open reading frame 66
C22ORF46 chromosome 22 open reading frame 46
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CADM3 cell adhesion molecule 3
CAV2 caveolin 2
CD8A CD8a molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CIZ1 CDKN1A interacting zinc finger protein 1
CLEC1B C-type lectin domain family 1, member B
CPB2 carboxypeptidase B2 (plasma)
CTNS cystinosin, lysosomal cystine transporter
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGAT1 diacylglycerol O-acyltransferase 1
DGCR8 DGCR8 microprocessor complex subunit
DKFZP434L187 uncharacterized LOC26082
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDNRA endothelin receptor type A
EPOR erythropoietin receptor
FAM153A family with sequence similarity 153, member A
FOXN3 forkhead box N3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GADD45G growth arrest and DNA-damage-inducible, gamma
GLS glutaminase
GMPR guanosine monophosphate reductase
GRM8 glutamate receptor, metabotropic 8
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXB6 homeobox B6
IFI6 interferon, alpha-inducible protein 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK3 Janus kinase 3
KREMEN2 kringle containing transmembrane protein 2
KRT8 keratin 8, type II
LIF leukemia inhibitory factor
LTBP2 latent transforming growth factor beta binding protein 2
MBD3 methyl-CpG binding domain protein 3
MED25 mediator complex subunit 25
MIER2 mesoderm induction early response 1, family member 2
MMP11 matrix metallopeptidase 11
MPL MPL proto-oncogene, thrombopoietin receptor
MR1 major histocompatibility complex, class I-related
MST1L macrophage stimulating 1-like
MTCP1 mature T-cell proliferation 1
MTL5 metallothionein-like 5, testis-specific (tesmin)
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAT6 N-acetyltransferase 6 (GCN5-related)
NDNF neuron-derived neurotrophic factor
NNAT neuronatin
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRN1 neuritin 1
OXCT2 3-oxoacid CoA transferase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFB platelet-derived growth factor beta polypeptide
PLK3 polo-like kinase 3
POLL polymerase (DNA directed), lambda
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAMEF10 PRAME family member 10
PRAMEF11 PRAME family member 11
PRKCI protein kinase C, iota
PTRF polymerase I and transcript release factor
RAB6B RAB6B, member RAS oncogene family
RHBDD3 rhomboid domain containing 3
RNF17 ring finger protein 17
RORC RAR-related orphan receptor C
RPL10 ribosomal protein L10
SAFB scaffold attachment factor B
SIK3 SIK family kinase 3
SLC45A2 solute carrier family 45, member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLIT1 slit homolog 1 (Drosophila)
SP4 Sp4 transcription factor
SPG20 spastic paraplegia 20 (Troyer syndrome)
STYK1 serine/threonine/tyrosine kinase 1
TCHH trichohyalin
TGFB2 transforming growth factor, beta 2
TLE2 transducin-like enhancer of split 2
TMEM212 transmembrane protein 212
TNC tenascin C
TP73-AS1 TP73 antisense RNA 1
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIB2 tribbles pseudokinase 2
TTC38 tetratricopeptide repeat domain 38
TUBA4B tubulin, alpha 4b
VIPR1 vasoactive intestinal peptide receptor 1
WDR62 WD repeat domain 62

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACBD4 acyl-CoA binding domain containing 4
ACTA1 actin, alpha 1, skeletal muscle
ADTRP androgen-dependent TFPI-regulating protein
AGMAT agmatine ureohydrolase (agmatinase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANP32A-IT1 ANP32A intronic transcript 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAG4 BCL2-associated athanogene 4
BCAS1 breast carcinoma amplified sequence 1
BCL9 B-cell CLL/lymphoma 9
BFSP1 beaded filament structural protein 1, filensin
BIRC7 baculoviral IAP repeat containing 7
C11ORF30 chromosome 11 open reading frame 30
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C3ORF18 chromosome 3 open reading frame 18
CPED1 cadherin-like and PC-esterase domain containing 1
DMTN dematin actin binding protein
DUSP13 dual specificity phosphatase 13
ENO3 enolase 3 (beta, muscle)
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM186A family with sequence similarity 186, member A
FRS2 fibroblast growth factor receptor substrate 2
FURIN furin (paired basic amino acid cleaving enzyme)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR143 G protein-coupled receptor 143
GPR157 G protein-coupled receptor 157
GSTM5 glutathione S-transferase mu 5
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2AE histone cluster 1, H2ae
HPN hepsin
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFT22 intraflagellar transport 22
IL2 interleukin 2
IL22 interleukin 22
INCENP inner centromere protein antigens 135/155kDa
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KEL Kell blood group, metallo-endopeptidase
KIAA0754 KIAA0754
KIAA0894 KIAA0894 protein
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LTC4S leukotriene C4 synthase
MAGEA5 melanoma antigen family A5
MAGEB2 melanoma antigen family B2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OVGP1 oviductal glycoprotein 1, 120kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PITX2 paired-like homeodomain 2
PMEL premelanosome protein
PODNL1 podocan-like 1
PRDM16 PR domain containing 16
PRF1 perforin 1 (pore forming protein)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTDSS2 phosphatidylserine synthase 2
PTPRS protein tyrosine phosphatase, receptor type, S
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIC8B RIC8 guanine nucleotide exchange factor B
RPAP2 RNA polymerase II associated protein 2
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SIPA1 signal-induced proliferation-associated 1
SOX12 SRY (sex determining region Y)-box 12
SPON2 spondin 2, extracellular matrix protein
STAB2 stabilin 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNC syncoilin, intermediate filament protein
TESC tescalcin
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM159 transmembrane protein 159
TMEM180 transmembrane protein 180
TRAPPC2 trafficking protein particle complex 2
TSPAN5 tetraspanin 5
TTC30A tetratricopeptide repeat domain 30A
VASH2 vasohibin 2
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB6 zinc finger and BTB domain containing 6
ZNF134 zinc finger protein 134
ZNF211 zinc finger protein 211
ZNF254 zinc finger protein 254
ZNF506 zinc finger protein 506
ZNF652 zinc finger protein 652