dantrolene-3786 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the dantrolene-3786 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
AQP1 aquaporin 1 (Colton blood group)
ARHGAP44 Rho GTPase activating protein 44
ATP9B ATPase, class II, type 9B
C7 complement component 7
C7ORF69 chromosome 7 open reading frame 69
C8ORF17 chromosome 8 open reading frame 17
CALB2 calbindin 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD2 CD2 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CLCA1 chloride channel accessory 1
CLTCL1 clathrin, heavy chain-like 1
CPN2 carboxypeptidase N, polypeptide 2
CRISP2 cysteine-rich secretory protein 2
DGCR6L DiGeorge syndrome critical region gene 6-like
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EMID1 EMI domain containing 1
EVI2B ecotropic viral integration site 2B
FILIP1L filamin A interacting protein 1-like
FRMPD1 FERM and PDZ domain containing 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAP43 growth associated protein 43
GAS2L1 growth arrest-specific 2 like 1
GAS7 growth arrest-specific 7
GM2A GM2 ganglioside activator
GPC3 glypican 3
GPR137 G protein-coupled receptor 137
GRTP1 growth hormone regulated TBC protein 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GTPBP1 GTP binding protein 1
HIST1H1T histone cluster 1, H1t
HRH4 histamine receptor H4
HSPA12A heat shock 70kDa protein 12A
IL36RN interleukin 36 receptor antagonist
ING4 inhibitor of growth family, member 4
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KDR kinase insert domain receptor
KIAA0319L KIAA0319-like
KIAA1024 KIAA1024
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
LARP7 La ribonucleoprotein domain family, member 7
LINC00115 long intergenic non-protein coding RNA 115
LIPE lipase, hormone-sensitive
LOXL3 lysyl oxidase-like 3
LSP1 lymphocyte-specific protein 1
MAPK14 mitogen-activated protein kinase 14
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MFAP2 microfibrillar-associated protein 2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MXD4 MAX dimerization protein 4
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NMT2 N-myristoyltransferase 2
NUMA1 nuclear mitotic apparatus protein 1
OPCML opioid binding protein/cell adhesion molecule-like
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PBOV1 prostate and breast cancer overexpressed 1
PCDHB3 protocadherin beta 3
PDGFB platelet-derived growth factor beta polypeptide
PDLIM5 PDZ and LIM domain 5
PKNOX1 PBX/knotted 1 homeobox 1
PTN pleiotrophin
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RSU1 Ras suppressor protein 1
RUNDC3A RUN domain containing 3A
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SOS2 son of sevenless homolog 2 (Drosophila)
SP1 Sp1 transcription factor
SPRR2B small proline-rich protein 2B
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
SULT4A1 sulfotransferase family 4A, member 1
SYMPK symplekin
TCF3 transcription factor 3
TLK1 tousled-like kinase 1
TNPO2 transportin 2
TRAF2 TNF receptor-associated factor 2
TSHZ2 teashirt zinc finger homeobox 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP53 ubiquitin specific peptidase 53
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
YTHDC2 YTH domain containing 2
ZBTB7A zinc finger and BTB domain containing 7A
ZNF516 zinc finger protein 516
ZNF646 zinc finger protein 646
ZNF674 zinc finger protein 674

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADAP2 ArfGAP with dual PH domains 2
ADGRB2 adhesion G protein-coupled receptor B2
ADGRL2 adhesion G protein-coupled receptor L2
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AKAP5 A kinase (PRKA) anchor protein 5
APOH apolipoprotein H (beta-2-glycoprotein I)
ARC activity-regulated cytoskeleton-associated protein
ARID3A AT rich interactive domain 3A (BRIGHT-like)
BCHE butyrylcholinesterase
BDKRB1 bradykinin receptor B1
BIRC7 baculoviral IAP repeat containing 7
C22ORF46 chromosome 22 open reading frame 46
CCDC85C coiled-coil domain containing 85C
CD3D CD3d molecule, delta (CD3-TCR complex)
CHM choroideremia (Rab escort protein 1)
CLDN17 claudin 17
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CRMP1 collapsin response mediator protein 1
CT55 cancer/testis antigen 55
CYTH3 cytohesin 3
DCAF13 DDB1 and CUL4 associated factor 13
DDN dendrin
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOC2A double C2-like domains, alpha
EGR1 early growth response 1
EPN1 epsin 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV6 ets variant 6
FGF1 fibroblast growth factor 1 (acidic)
FOXO4 forkhead box O4
GAL3ST4 galactose-3-O-sulfotransferase 4
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIF gastric intrinsic factor (vitamin B synthesis)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR1 G protein-coupled receptor 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HDAC7 histone deacetylase 7
HLA-DMB major histocompatibility complex, class II, DM beta
HOXA6 homeobox A6
HSPA1L heat shock 70kDa protein 1-like
IFNA17 interferon, alpha 17
IL22 interleukin 22
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLF3 Kruppel-like factor 3 (basic)
LINC00472 long intergenic non-protein coding RNA 472
LMTK2 lemur tyrosine kinase 2
LPAR6 lysophosphatidic acid receptor 6
LRRC2 leucine rich repeat containing 2
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LRRK1 leucine-rich repeat kinase 1
LY86 lymphocyte antigen 86
MCOLN3 mucolipin 3
MILR1 mast cell immunoglobulin-like receptor 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP2 matrix metallopeptidase 2
MN1 meningioma (disrupted in balanced translocation) 1
MUC3A mucin 3A, cell surface associated
NOVA1 neuro-oncological ventral antigen 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5M 5',3'-nucleotidase, mitochondrial
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI1 peptidyl arginine deiminase, type I
PALM paralemmin
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGLYRP1 peptidoglycan recognition protein 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POU3F2 POU class 3 homeobox 2
PRPH peripherin
PTPRS protein tyrosine phosphatase, receptor type, S
RFPL1S RFPL1 antisense RNA 1
RIN1 Ras and Rab interactor 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
SAA4 serum amyloid A4, constitutive
SIRAL2 SIR2 antiphage like 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SSTR5 somatostatin receptor 5
TBL1Y transducin (beta)-like 1, Y-linked
THRB thyroid hormone receptor, beta
TRAC T cell receptor alpha constant
TRPV6 transient receptor potential cation channel, subfamily V, member 6
USP19 ubiquitin specific peptidase 19
VASH1 vasohibin 1
WNT5B wingless-type MMTV integration site family, member 5B
WT1-AS WT1 antisense RNA
XYLT2 xylosyltransferase II
ZNF219 zinc finger protein 219
ZNF276 zinc finger protein 276
ZNF37BP zinc finger protein 37B, pseudogene
ZNF639 zinc finger protein 639
ZNF74 zinc finger protein 74
ZNF768 zinc finger protein 768