dapsone-1827 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the dapsone-1827 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGGF1 angiogenic factor with G patch and FHA domains 1
ANKRD12 ankyrin repeat domain 12
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APH1A APH1A gamma secretase subunit
APOL2 apolipoprotein L, 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
AXL AXL receptor tyrosine kinase
BAX BCL2-associated X protein
C11ORF30 chromosome 11 open reading frame 30
C17ORF85 chromosome 17 open reading frame 85
C4ORF29 chromosome 4 open reading frame 29
CD82 CD82 molecule
CEP290 centrosomal protein 290kDa
CHN2 chimerin 2
COG5 component of oligomeric golgi complex 5
COL4A6 collagen, type IV, alpha 6
CTSZ cathepsin Z
CUL7 cullin 7
DBT dihydrolipoamide branched chain transacylase E2
DCAF13 DDB1 and CUL4 associated factor 13
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DLL3 delta-like 3 (Drosophila)
EML2 echinoderm microtubule associated protein like 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EYA4 EYA transcriptional coactivator and phosphatase 4
FDX1 ferredoxin 1
FSCN1 fascin actin-bundling protein 1
GOSR2 golgi SNAP receptor complex member 2
GPR137 G protein-coupled receptor 137
HIRA histone cell cycle regulator
HIST1H3G histone cluster 1, H3g
HMOX1 heme oxygenase 1
HOOK1 hook microtubule-tethering protein 1
HP1BP3 heterochromatin protein 1, binding protein 3
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JMJD6 jumonji domain containing 6
KIFC1 kinesin family member C1
KRT86 keratin 86, type II
LARP4B La ribonucleoprotein domain family, member 4B
LMNB1 lamin B1
LPIN2 lipin 2
MET MET proto-oncogene, receptor tyrosine kinase
METTL3 methyltransferase like 3
MON1B MON1 secretory trafficking family member B
MX1 MX dynamin-like GTPase 1
N4BP1 NEDD4 binding protein 1
NDE1 nudE neurodevelopment protein 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NPEPL1 aminopeptidase-like 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP160 nucleoporin 160kDa
PALMD palmdelphin
PGAP1 post-GPI attachment to proteins 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
RBM12 RNA binding motif protein 12
RBM3 RNA binding motif (RNP1, RRM) protein 3
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPL23AP7 ribosomal protein L23a pseudogene 7
RPL31 ribosomal protein L31
SERINC3 serine incorporator 3
SFTPB surfactant protein B
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC25A44 solute carrier family 25, member 44
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SRRM2 serine/arginine repetitive matrix 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYK spleen tyrosine kinase
TAZ tafazzin
TBCD tubulin folding cofactor D
TCAF1 TRPM8 channel-associated factor 1
TFCP2 transcription factor CP2
TNK1 tyrosine kinase, non-receptor, 1
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TTC38 tetratricopeptide repeat domain 38
TUBA3C tubulin, alpha 3c
UTRN utrophin
VEGFA vascular endothelial growth factor A
WDR60 WD repeat domain 60
WWOX WW domain containing oxidoreductase
ZFHX3 zinc finger homeobox 3
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF286A zinc finger protein 286A
ZNF358 zinc finger protein 358
ZNF580 zinc finger protein 580
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPK1 alpha-kinase 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ASAP1-IT1 ASAP1 intronic transcript 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BIRC3 baculoviral IAP repeat containing 3
C17ORF70 chromosome 17 open reading frame 70
C7ORF43 chromosome 7 open reading frame 43
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CARD8 caspase recruitment domain family, member 8
CCNT1 cyclin T1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CFD complement factor D (adipsin)
CGREF1 cell growth regulator with EF-hand domain 1
CHMP6 charged multivesicular body protein 6
CLCF1 cardiotrophin-like cytokine factor 1
CLDN15 claudin 15
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CPEB1 cytoplasmic polyadenylation element binding protein 1
CXCL3 chemokine (C-X-C motif) ligand 3
DCLRE1B DNA cross-link repair 1B
DEAF1 DEAF1 transcription factor
DHRS9 dehydrogenase/reductase (SDR family) member 9
EDN1 endothelin 1
EFNA3 ephrin-A3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM53B family with sequence similarity 53, member B
FAM86C1 family with sequence similarity 86, member C1
FBXW12 F-box and WD repeat domain containing 12
FZD8 frizzled class receptor 8
GAL3ST4 galactose-3-O-sulfotransferase 4
GALK1 galactokinase 1
GLS2 glutaminase 2 (liver, mitochondrial)
GMIP GEM interacting protein
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPX2 glutathione peroxidase 2
GTPBP3 GTP binding protein 3 (mitochondrial)
HIST1H2AG histone cluster 1, H2ag
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HYAL3 hyaluronoglucosaminidase 3
HYI hydroxypyruvate isomerase (putative)
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
JAM3 junctional adhesion molecule 3
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIFC3 kinesin family member C3
LRP5L low density lipoprotein receptor-related protein 5-like
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MACROD1 MACRO domain containing 1
MAL mal, T-cell differentiation protein
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MNX1 motor neuron and pancreas homeobox 1
MRPL52 mitochondrial ribosomal protein L52
MUC3A mucin 3A, cell surface associated
MXRA8 matrix-remodelling associated 8
NCS1 neuronal calcium sensor 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHEJ1 nonhomologous end-joining factor 1
NPR3 natriuretic peptide receptor 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
ODF2 outer dense fiber of sperm tails 2
OVGP1 oviductal glycoprotein 1, 120kDa
PARP3 poly (ADP-ribose) polymerase family, member 3
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLD3 phospholipase D family, member 3
PMCH pro-melanin-concentrating hormone
POLH polymerase (DNA directed), eta
PTCD2 pentatricopeptide repeat domain 2
RIN1 Ras and Rab interactor 1
RNF2 ring finger protein 2
RPH3AL rabphilin 3A-like (without C2 domains)
RUNX1-IT1 RUNX1 intronic transcript 1
RUSC2 RUN and SH3 domain containing 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SHPK sedoheptulokinase
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC35F6 solute carrier family 35, member F6
SLC44A4 solute carrier family 44, member 4
SMA4 glucuronidase, beta pseudogene
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX12 SRY (sex determining region Y)-box 12
SPATA2L spermatogenesis associated 2-like
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TAGLN3 transgelin 3
TMEM132A transmembrane protein 132A
TOE1 target of EGR1, member 1 (nuclear)
TPRA1 transmembrane protein, adipocyte asscociated 1
TSC22D4 TSC22 domain family, member 4
TSKU tsukushi, small leucine rich proteoglycan
UNKL unkempt family zinc finger-like
ZNF574 zinc finger protein 574