daxx Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description death-domain associated protein|This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] (NCBI Entrez Gene Database, 1616)
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Genes

50 genes co-occuring with the biological term daxx in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AIRE autoimmune regulator
ATRX alpha thalassemia/mental retardation syndrome X-linked
CCL5 chemokine (C-C motif) ligand 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CFLAR CASP8 and FADD-like apoptosis regulator
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL3 cullin 3
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
DAPK3 death-associated protein kinase 3
DAXX death-domain associated protein
DEK DEK proto-oncogene
EIF4B eukaryotic translation initiation factor 4B
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAS Fas cell surface death receptor
FTH1 ferritin, heavy polypeptide 1
H3F3A H3 histone, family 3A
H3F3B H3 histone, family 3B (H3.3B)
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
KPNA4 karyopherin alpha 4 (importin alpha 3)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MIR21 microRNA 21
PARK7 parkinson protein 7
PAWR PRKC, apoptosis, WT1, regulator
PAX5 paired box 5
PIAS1 protein inhibitor of activated STAT, 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PML promyelocytic leukemia
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD4 SMAD family member 4
SP100 SP100 nuclear antigen
SPOP speckle-type POZ protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUMO1 small ubiquitin-like modifier 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TP53 tumor protein p53
TSG101 tumor susceptibility 101
UBE2I ubiquitin-conjugating enzyme E2I
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)