death-inducing signaling complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. (Gene Ontology, GO_0031264)
Similar Terms
Downloads & Tools


8 proteins localized to the death-inducing signaling complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
FADD Fas (TNFRSF6)-associated via death domain 0.663342
TRADD TNFRSF1A-associated via death domain 0.663342
FAF1 Fas (TNFRSF6) associated factor 1 0.663342
CFLAR CASP8 and FADD-like apoptosis regulator 0.663342
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.663342
FAS Fas cell surface death receptor 0.663342
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.663342
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.237908