debrisoquine-5288 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the debrisoquine-5288 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APP amyloid beta (A4) precursor protein
ASPH aspartate beta-hydroxylase
ATG9A autophagy related 9A
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL7A B-cell CLL/lymphoma 7A
BCL9 B-cell CLL/lymphoma 9
BICD1 bicaudal D homolog 1 (Drosophila)
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C2ORF27A chromosome 2 open reading frame 27A
C7ORF43 chromosome 7 open reading frame 43
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC6 coiled-coil domain containing 6
CD3EAP CD3e molecule, epsilon associated protein
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CIC capicua transcriptional repressor
CLASP1 cytoplasmic linker associated protein 1
CRABP1 cellular retinoic acid binding protein 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSCR3 Down syndrome critical region 3
EHD1 EH-domain containing 1
EML3 echinoderm microtubule associated protein like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FBXL15 F-box and leucine-rich repeat protein 15
FKBP10 FK506 binding protein 10, 65 kDa
FRMD4A FERM domain containing 4A
FZD7 frizzled class receptor 7
GALNS galactosamine (N-acetyl)-6-sulfatase
GRK5 G protein-coupled receptor kinase 5
GTPBP3 GTP binding protein 3 (mitochondrial)
HCFC1 host cell factor C1
HDLBP high density lipoprotein binding protein
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H2BC histone cluster 1, H2bc
HNMT histamine N-methyltransferase
ICAM1 intercellular adhesion molecule 1
IL1R1 interleukin 1 receptor, type I
IL5RA interleukin 5 receptor, alpha
IPO9 importin 9
ITPK1 inositol-tetrakisphosphate 1-kinase
JAG2 jagged 2
KHSRP KH-type splicing regulatory protein
LAMA5 laminin, alpha 5
LARP6 La ribonucleoprotein domain family, member 6
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTRF1L mitochondrial translational release factor 1-like
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit
NCKAP1 NCK-associated protein 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
OGFR opioid growth factor receptor
OGG1 8-oxoguanine DNA glycosylase
OSBPL2 oxysterol binding protein-like 2
PBX2 pre-B-cell leukemia homeobox 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PC pyruvate carboxylase
PDCD6 programmed cell death 6
PEX26 peroxisomal biogenesis factor 26
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PODXL podocalyxin-like
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
QPRT quinolinate phosphoribosyltransferase
RAB5C RAB5C, member RAS oncogene family
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBM5 RNA binding motif protein 5
RBM8A RNA binding motif protein 8A
RNF19B ring finger protein 19B
RPGR retinitis pigmentosa GTPase regulator
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEC23IP SEC23 interacting protein
SIN3B SIN3 transcription regulator family member B
SIRT6 sirtuin 6
SKA1 spindle and kinetochore associated complex subunit 1
SKI SKI proto-oncogene
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
SRRM2 serine/arginine repetitive matrix 2
STK25 serine/threonine kinase 25
STXBP6 syntaxin binding protein 6 (amisyn)
SYNJ2 synaptojanin 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TESK1 testis-specific kinase 1
TMF1 TATA element modulatory factor 1
TTC9 tetratricopeptide repeat domain 9
TTLL3 tubulin tyrosine ligase-like family member 3
WDR62 WD repeat domain 62
WNK1 WNK lysine deficient protein kinase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACP2 acid phosphatase 2, lysosomal
ADAM15 ADAM metallopeptidase domain 15
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ASB9 ankyrin repeat and SOCS box containing 9
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CAPG capping protein (actin filament), gelsolin-like
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDKL3 cyclin-dependent kinase-like 3
CEP97 centrosomal protein 97kDa
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTNNBIP1 catenin, beta interacting protein 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
ECHDC3 enoyl CoA hydratase domain containing 3
EDC3 enhancer of mRNA decapping 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ERCC4 excision repair cross-complementation group 4
FAM86C1 family with sequence similarity 86, member C1
FBXO46 F-box protein 46
FBXW12 F-box and WD repeat domain containing 12
FKBP14 FK506 binding protein 14, 22 kDa
FMO4 flavin containing monooxygenase 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L2 galactosidase, beta 1-like 2
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HELLS helicase, lymphoid-specific
HIRA histone cell cycle regulator
HIST1H1E histone cluster 1, H1e
HMGB3P1 high mobility group box 3 pseudogene 1
HP1BP3 heterochromatin protein 1, binding protein 3
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
IPP intracisternal A particle-promoted polypeptide
ISG15 ISG15 ubiquitin-like modifier
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL8 methyltransferase like 8
MFSD11 major facilitator superfamily domain containing 11
MITF microphthalmia-associated transcription factor
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PECR peroxisomal trans-2-enoyl-CoA reductase
PLD3 phospholipase D family, member 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRICKLE3 prickle homolog 3 (Drosophila)
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
RIBC2 RIB43A domain with coiled-coils 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF146 ring finger protein 146
RSRC1 arginine/serine-rich coiled-coil 1
SCD5 stearoyl-CoA desaturase 5
SDF2L1 stromal cell-derived factor 2-like 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC25A40 solute carrier family 25, member 40
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SNX15 sorting nexin 15
SSBP3 single stranded DNA binding protein 3
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STK19 serine/threonine kinase 19
SUSD4 sushi domain containing 4
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TDRD1 tudor domain containing 1
THOP1 thimet oligopeptidase 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM230 transmembrane protein 230
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II
ZNF160 zinc finger protein 160
ZNF205 zinc finger protein 205
ZNF430 zinc finger protein 430
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF665 zinc finger protein 665
ZNF721 zinc finger protein 721
ZSCAN5A zinc finger and SCAN domain containing 5A