debrisoquine-6688 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the debrisoquine-6688 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADAM8 ADAM metallopeptidase domain 8
ADARB1 adenosine deaminase, RNA-specific, B1
ALDOB aldolase B, fructose-bisphosphate
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGAP26 Rho GTPase activating protein 26
ARR3 arrestin 3, retinal (X-arrestin)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATXN2L ataxin 2-like
BAX BCL2-associated X protein
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCDC85C coiled-coil domain containing 85C
CDC25C cell division cycle 25C
CEP135 centrosomal protein 135kDa
CFHR4 complement factor H-related 4
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CNGB3 cyclic nucleotide gated channel beta 3
CNOT4 CCR4-NOT transcription complex, subunit 4
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTSF cathepsin F
DRD2 dopamine receptor D2
EFNA3 ephrin-A3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV6 ets variant 6
FAIM2 Fas apoptotic inhibitory molecule 2
FAM63A family with sequence similarity 63, member A
FAM63B family with sequence similarity 63, member B
FGFR1 fibroblast growth factor receptor 1
GLP1R glucagon-like peptide 1 receptor
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GTPBP1 GTP binding protein 1
H2AFX H2A histone family, member X
HAPLN1 hyaluronan and proteoglycan link protein 1
HAUS5 HAUS augmin-like complex, subunit 5
HEG1 heart development protein with EGF-like domains 1
HEMK1 HemK methyltransferase family member 1
HIPK3 homeodomain interacting protein kinase 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL33 interleukin 33
JUND jun D proto-oncogene
KIAA1467 KIAA1467
KLK12 kallikrein-related peptidase 12
KMT2A lysine (K)-specific methyltransferase 2A
LEF1 lymphoid enhancer-binding factor 1
LIPG lipase, endothelial
LRRC2 leucine rich repeat containing 2
LRTM1 leucine-rich repeats and transmembrane domains 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTBP4 latent transforming growth factor beta binding protein 4
MDM4 MDM4, p53 regulator
MIER2 mesoderm induction early response 1, family member 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NBEAL2 neurobeachin-like 2
NEK9 NIMA-related kinase 9
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NRP2 neuropilin 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBOV1 prostate and breast cancer overexpressed 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHF14 PHD finger protein 14
PHF7 PHD finger protein 7
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLK4 polo-like kinase 4
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP5C protein phosphatase 5, catalytic subunit
PRKG2 protein kinase, cGMP-dependent, type II
PXN paxillin
RAB31 RAB31, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
SIGLEC8 sialic acid binding Ig-like lectin 8
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SRSF5 serine/arginine-rich splicing factor 5
TBC1D5 TBC1 domain family, member 5
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM156 transmembrane protein 156
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRD T cell receptor delta locus
TRPC5 transient receptor potential cation channel, subfamily C, member 5
UTRN utrophin
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
YTHDC2 YTH domain containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZC3H11A zinc finger CCCH-type containing 11A
ZMYND8 zinc finger, MYND-type containing 8
ZNF24 zinc finger protein 24
ZNF287 zinc finger protein 287
ZNF428 zinc finger protein 428
ZNF783 zinc finger family member 783
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADAM2 ADAM metallopeptidase domain 2
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARMCX4 armadillo repeat containing, X-linked 4
AURKC aurora kinase C
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BEX1 brain expressed, X-linked 1
C1ORF54 chromosome 1 open reading frame 54
CA11 carbonic anhydrase XI
CCDC186 coiled-coil domain containing 186
CDH7 cadherin 7, type 2
CEMIP cell migration inducing protein, hyaluronan binding
CEMP1 cementum protein 1
CES3 carboxylesterase 3
CHPF chondroitin polymerizing factor
CHRDL1 chordin-like 1
CLCN6 chloride channel, voltage-sensitive 6
CLDN11 claudin 11
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPED1 cadherin-like and PC-esterase domain containing 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYBA2 crystallin, beta A2
CSF1R colony stimulating factor 1 receptor
DDN dendrin
DENND2D DENN/MADD domain containing 2D
DEPTOR DEP domain containing MTOR-interacting protein
DNAH17 dynein, axonemal, heavy chain 17
DTX2 deltex 2, E3 ubiquitin ligase
FKBP10 FK506 binding protein 10, 65 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT4 fms-related tyrosine kinase 4
FMO4 flavin containing monooxygenase 4
GEMIN8 gem (nuclear organelle) associated protein 8
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRAMD1C GRAM domain containing 1C
GSTA3 glutathione S-transferase alpha 3
HIST1H2AK histone cluster 1, H2ak
HIST1H3I histone cluster 1, H3i
HIST2H2AA3 histone cluster 2, H2aa3
HOXC5 homeobox C5
IDI2-AS1 IDI2 antisense RNA 1
IER3IP1 immediate early response 3 interacting protein 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL36RN interleukin 36 receptor antagonist
KIRREL kin of IRRE like (Drosophila)
KLC2 kinesin light chain 2
KRT31 keratin 31, type I
KRT9 keratin 9, type I
LOC100287590 uncharacterized LOC100287590
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYPD3 LY6/PLAUR domain containing 3
MCC mutated in colorectal cancers
MRPL41 mitochondrial ribosomal protein L41
MRPL52 mitochondrial ribosomal protein L52
MTSS1L metastasis suppressor 1-like
NPM3 nucleophosmin/nucleoplasmin 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PARM1 prostate androgen-regulated mucin-like protein 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDH12 protocadherin 12
PCDHA9 protocadherin alpha 9
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEX26 peroxisomal biogenesis factor 26
PODXL2 podocalyxin-like 2
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRDM14 PR domain containing 14
PRF1 perforin 1 (pore forming protein)
PRSS22 protease, serine, 22
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAG2 recombination activating gene 2
RAPSN receptor-associated protein of the synapse
ROM1 retinal outer segment membrane protein 1
SCIN scinderin
SGK2 serum/glucocorticoid regulated kinase 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPINK5 serine peptidase inhibitor, Kazal type 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCEAL2 transcription elongation factor A (SII)-like 2
TMEM132A transmembrane protein 132A
TMSB15A thymosin beta 15a
TSC22D4 TSC22 domain family, member 4
TUBA4B tubulin, alpha 4b
UBQLN4 ubiquilin 4
WDR62 WD repeat domain 62
XDH xanthine dehydrogenase
XYLT2 xylosyltransferase II
ZBTB22 zinc finger and BTB domain containing 22
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF197 zinc finger protein 197
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253