decline Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

281 genes co-occuring with the biological term decline in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACE angiotensin I converting enzyme
ADAM33 ADAM metallopeptidase domain 33
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGTR1 angiotensin II receptor, type 1
AHSG alpha-2-HS-glycoprotein
AICDA activation-induced cytidine deaminase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMH anti-Mullerian hormone
ANGPT2 angiopoietin 2
APLN apelin
APOD apolipoprotein D
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
APP amyloid beta (A4) precursor protein
APTX aprataxin
AQP5 aquaporin 5
ARSB arylsulfatase B
ATP13A2 ATPase type 13A2
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BACE1 beta-site APP-cleaving enzyme 1
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCR breakpoint cluster region
BDNF brain-derived neurotrophic factor
BMP15 bone morphogenetic protein 15
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C9ORF72 chromosome 9 open reading frame 72
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD28 CD28 molecule
CD34 CD34 molecule
CDC6 cell division cycle 6
CETP cholesteryl ester transfer protein, plasma
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIA chitinase, acidic
CHIT1 chitinase 1 (chitotriosidase)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLU clusterin
COMT catechol-O-methyltransferase
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPLX2 complexin 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CSN2 casein beta
CST3 cystatin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYB5R3 cytochrome b5 reductase 3
CYBB cytochrome b-245, beta polypeptide
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFB1 defensin, beta 1
DIO2 deiodinase, iodothyronine, type II
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
DUSP6 dual specificity phosphatase 6
E2F3 E2F transcription factor 3
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPO erythropoietin
ESR1 estrogen receptor 1
FABP1 fatty acid binding protein 1, liver
FBXO7 F-box protein 7
FGF2 fibroblast growth factor 2 (basic)
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FMR1 fragile X mental retardation 1
FOXP3 forkhead box P3
FTO fat mass and obesity associated
G6PD glucose-6-phosphate dehydrogenase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GC group-specific component (vitamin D binding protein)
GDF15 growth differentiation factor 15
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GLCCI1 glucocorticoid induced 1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPER1 G protein-coupled estrogen receptor 1
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GSTCD glutathione S-transferase, C-terminal domain containing
GSTP1 glutathione S-transferase pi 1
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-B major histocompatibility complex, class I, B
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTT huntingtin
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNA1 interferon, alpha 1
IFNL3 interferon, lambda 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL33R interleukin 33 receptor
IL4R interleukin 4 receptor
IL6 interleukin 6
INS insulin
IRF4 interferon regulatory factor 4
ITGA1 integrin, alpha 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JAK2 Janus kinase 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KLK3 kallikrein-related peptidase 3
LCN2 lipocalin 2
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LMNA lamin A/C
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LRP1B low density lipoprotein receptor-related protein 1B
LRP2 low density lipoprotein receptor-related protein 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MALT1 MALT1 paracaspase
MAP2 microtubule-associated protein 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MBL2 mannose-binding lectin (protein C) 2, soluble
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR200A microRNA 200a
MIR21 microRNA 21
MIR216A microRNA 216a
MIR223 microRNA 223
MME membrane metallo-endopeptidase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC16 mucin 16, cell surface associated
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NGF nerve growth factor (beta polypeptide)
NNT nicotinamide nucleotide transhydrogenase
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH4 notch 4
NPC1 Niemann-Pick disease, type C1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPPB natriuretic peptide B
NQO2 NAD(P)H dehydrogenase, quinone 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTN1 netrin 1
PGR progesterone receptor
PICALM phosphatidylinositol binding clathrin assembly protein
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNP purine nucleoside phosphorylase
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRNP prion protein
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PSEN1 presenilin 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
QPCT glutaminyl-peptide cyclotransferase
RAB27A RAB27A, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RBBP4 retinoblastoma binding protein 4
RBP4 retinol binding protein 4, plasma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RELN reelin
RS1 retinoschisin 1
S100B S100 calcium binding protein B
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPA1 surfactant protein A1
SHBG sex hormone-binding globulin
SHH sonic hedgehog
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIRT6 sirtuin 6
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOAT1 sterol O-acyltransferase 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPAST spastin
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TARDBP TAR DNA binding protein
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TJP1 tight junction protein 1
TKTL1 transketolase-like 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNS1 tensin 1
TP53 tumor protein p53
UMOD uromodulin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
WNT9A wingless-type MMTV integration site family, member 9A
WT1 Wilms tumor 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFPM2 zinc finger protein, FOG family member 2