decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Gene Set

Dataset IMPC Knockout Mouse Phenotypes
Category disease or phenotype associations
Type phenotype
Description a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release (Mammalian Phenotype Ontology, MP_0010169)
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Genes

4 gene knockouts causing the decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number phenotype in mic from the IMPC Knockout Mouse Phenotypes dataset.

Symbol Name
CARD11 caspase recruitment domain family, member 11
CD27 CD27 molecule
CD38 CD38 molecule
GMDS GDP-mannose 4,6-dehydratase