decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Gene Set

Dataset	MGI Mouse Phenotype Associations 2023
Category	disease or phenotype associations
Type	phenotype
Description	a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release (Mammalian Phenotype Ontology, MP_0010169)
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Genes

16 gene mutations causing the decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol	Name
BATF	basic leucine zipper transcription factor, ATF-like
CARD11	caspase recruitment domain family, member 11
CD27	CD27 molecule
CD38	CD38 molecule
DIAPH1	diaphanous-related formin 1
ELMO1	engulfment and cell motility 1
FOXP3	forkhead box P3
GMDS	GDP-mannose 4,6-dehydratase
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKZF1	IKAROS family zinc finger 1 (Ikaros)
IL2	interleukin 2
ITK	IL2-inducible T-cell kinase
PTPN6	protein tyrosine phosphatase, non-receptor type 6
RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)
THEMIS	thymocyte selection associated
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa