decreased angiogenesis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network (Mammalian Phenotype Ontology, MP_0005602)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005602
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Genes

63 gene mutations causing the decreased angiogenesis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABI1 abl-interactor 1
AGTR2 angiotensin II receptor, type 2
ANGPT1 angiopoietin 1
ANGPTL4 angiopoietin-like 4
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
CCDC88A coiled-coil domain containing 88A
CCL13 chemokine (C-C motif) ligand 13
CCM2 cerebral cavernous malformation 2
CD151 CD151 molecule (Raph blood group)
CD44 CD44 molecule (Indian blood group)
CDH5 cadherin 5, type 2 (vascular endothelium)
CHM choroideremia (Rab escort protein 1)
CLIC4 chloride intracellular channel 4
CREBBP CREB binding protein
CTGF connective tissue growth factor
CTSS cathepsin S
DCBLD2 discoidin, CUB and LCCL domain containing 2
EGFL7 EGF-like-domain, multiple 7
ENG endoglin
EPO erythropoietin
EPOR erythropoietin receptor
ESAM endothelial cell adhesion molecule
F11R F11 receptor
FBLN5 fibulin 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FZD4 frizzled class receptor 4
G6PD glucose-6-phosphate dehydrogenase
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICAM1 intercellular adhesion molecule 1
ITGB4 integrin, beta 4
KLF5 Kruppel-like factor 5 (intestinal)
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK7 mitogen-activated protein kinase 7
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
NOSTRIN nitric oxide synthase trafficking
NOTCH1 notch 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRARP NOTCH-regulated ankyrin repeat protein
NRP1 neuropilin 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PKNOX1 PBX/knotted 1 homeobox 1
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLG plasminogen
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAP1A RAP1A, member of RAS oncogene family
RNF7 ring finger protein 7
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RUNX2 runt-related transcription factor 2
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMAD5 SMAD family member 5
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
VASH2 vasohibin 2
VEGFA vascular endothelial growth factor A