decreased brain sterol level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced level in the brain of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated (Mammalian Phenotype Ontology, MP_0012227)
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6 gene mutations causing the decreased brain sterol level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APOE apolipoprotein E
DHCR7 7-dehydrocholesterol reductase
MBP myelin basic protein
NPC1 Niemann-Pick disease, type C1
SC5D sterol-C5-desaturase
SREBF2 sterol regulatory element binding transcription factor 2