decreased circulating interferon-alpha level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells (Mammalian Phenotype Ontology, MP_0008574)
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8 gene mutations causing the decreased circulating interferon-alpha level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
FLT3 fms-related tyrosine kinase 3
IFNB1 interferon, beta 1, fibroblast
MAVS mitochondrial antiviral signaling protein
MB21D1 Mab-21 domain containing 1
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
RSAD2 radical S-adenosyl methionine domain containing 2
TLR7 toll-like receptor 7
TMEM173 transmembrane protein 173