decreased circulating interferon-beta level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity (Mammalian Phenotype Ontology, MP_0008576)
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6 gene mutations causing the decreased circulating interferon-beta level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
IFNB1 interferon, beta 1, fibroblast
MAVS mitochondrial antiviral signaling protein
MB21D1 Mab-21 domain containing 1
PELI1 pellino E3 ubiquitin protein ligase 1
TMEM173 transmembrane protein 173