decreased circulating interleukin-1 beta level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane (Mammalian Phenotype Ontology, MP_0008642)
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17 gene mutations causing the decreased circulating interleukin-1 beta level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CASP4 caspase 4, apoptosis-related cysteine peptidase
F3 coagulation factor III (thromboplastin, tissue factor)
GBP5 guanylate binding protein 5
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL1B interleukin 1, beta
IL6R interleukin 6 receptor
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP3 NLR family, pyrin domain containing 3
PARP1 poly (ADP-ribose) polymerase 1
PILRB paired immunoglobin-like type 2 receptor beta
PRKCE protein kinase C, epsilon
PYCARD PYD and CARD domain containing
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A