decreased circulating thyroxine level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism (Mammalian Phenotype Ontology, MP_0005478)
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33 gene mutations causing the decreased circulating thyroxine level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CRYM crystallin, mu
CYBA cytochrome b-245, alpha polypeptide
DIO3 deiodinase, iodothyronine, type III
DUOX2 dual oxidase 2
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GHR growth hormone receptor
KLC2 kinesin light chain 2
LEPROT leptin receptor overlapping transcript
LHX3 LIM homeobox 3
MED1 mediator complex subunit 1
NCOR1 nuclear receptor corepressor 1
OAT ornithine aminotransferase
PAX8 paired box 8
PDYN prodynorphin
POMC proopiomelanocortin
RUNX2 runt-related transcription factor 2
SIRT1 sirtuin 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SSFA2 sperm specific antigen 2
TG thyroglobulin
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TPST2 tyrosylprotein sulfotransferase 2
TRH thyrotropin-releasing hormone
TRHR thyrotropin-releasing hormone receptor
TSHR thyroid stimulating hormone receptor
TTR transthyretin
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VGF VGF nerve growth factor inducible
WDR37 WD repeat domain 37