decreased circulating tumor necrosis factor level Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium (Mammalian Phenotype Ontology, MP_0008554)
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Genes

54 gene mutations causing the decreased circulating tumor necrosis factor level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARID5A AT rich interactive domain 5A (MRF1-like)
BBS12 Bardet-Biedl syndrome 12
C3 complement component 3
CD14 CD14 molecule
CD19 CD19 molecule
CD44 CD44 molecule (Indian blood group)
CLIC4 chloride intracellular channel 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FFAR2 free fatty acid receptor 2
FOXN1 forkhead box N1
FOXO1 forkhead box O1
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
IFI35 interferon-induced protein 35
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNGR1 interferon gamma receptor 1
IL22 interleukin 22
IL6R interleukin 6 receptor
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
LACC1 laccase (multicopper oxidoreductase) domain containing 1
LEP leptin
LRRC19 leucine rich repeat containing 19
LRRC8E leucine rich repeat containing 8 family, member E
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MSMP microseminoprotein, prostate associated
MSTN myostatin
MYD88 myeloid differentiation primary response 88
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NKG7 natural killer cell granule protein 7
NMI N-myc (and STAT) interactor
NPY1R neuropeptide Y receptor Y1
PARP1 poly (ADP-ribose) polymerase 1
PELI1 pellino E3 ubiquitin protein ligase 1
PILRB paired immunoglobin-like type 2 receptor beta
PRKCE protein kinase C, epsilon
PYHIN1 pyrin and HIN domain family, member 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
S100A9 S100 calcium binding protein A9
SGMS1 sphingomyelin synthase 1
SIGLECL1 SIGLEC family like 1
SNX8 sorting nexin 8
SRA1 steroid receptor RNA activator 1
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TRADD TNFRSF1A-associated via death domain
ZDHHC1 zinc finger, DHHC-type containing 1