decreased dopaminergic neuron number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter (Mammalian Phenotype Ontology, MP_0011448)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011448
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Genes

18 gene mutations causing the decreased dopaminergic neuron number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
DRD2 dopamine receptor D2
EN1 engrailed homeobox 1
FERD3L Fer3-like bHLH transcription factor
HIPK2 homeodomain interacting protein kinase 2
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
LMX1A LIM homeobox transcription factor 1, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PITX3 paired-like homeodomain 3
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCG synuclein, gamma (breast cancer-specific protein 1)
TGFB2 transforming growth factor, beta 2
TSHR thyroid stimulating hormone receptor
Funding