decreased fibroblast proliferation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the expansion rate of a fibroblast cell population by cell division (Mammalian Phenotype Ontology, MP_0011704)
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83 gene mutations causing the decreased fibroblast proliferation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGAP1 Rho GTPase activating protein 1
ATM ATM serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBX2 chromobox homolog 2
CD44 CD44 molecule (Indian blood group)
CDK7 cyclin-dependent kinase 7
CIRBP cold inducible RNA binding protein
CTC1 CTS telomere maintenance complex component 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNM1L dynamin 1-like
DPH1 diphthamide biosynthesis 1
DSG2 desmoglein 2
EP300 E1A binding protein p300
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FNTB farnesyltransferase, CAAX box, beta
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GLRX3 glutaredoxin 3
HAT1 histone acetyltransferase 1
HDGFRP2 hepatoma-derived growth factor-related protein 2
HSPB1 heat shock 27kDa protein 1
HUS1 HUS1 checkpoint homolog (S. pombe)
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUN jun proto-oncogene
JUND jun D proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KMT2A lysine (K)-specific methyltransferase 2A
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LMNA lamin A/C
LZTS1 leucine zipper, putative tumor suppressor 1
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK3 mitogen-activated protein kinase 3
MASTL microtubule associated serine/threonine kinase-like
MCM4 minichromosome maintenance complex component 4
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MED1 mediator complex subunit 1
MED31 mediator complex subunit 31
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIS18A MIS18 kinetochore protein A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCOA6 nuclear receptor coactivator 6
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHC2 polyhomeotic homolog 2 (Drosophila)
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
POLB polymerase (DNA directed), beta
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP5C protein phosphatase 5, catalytic subunit
PRMT6 protein arginine methyltransferase 6
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTK2 protein tyrosine kinase 2
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RECQL RecQ helicase-like
RHEB Ras homolog enriched in brain
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPL29 ribosomal protein L29
SERTAD2 SERTA domain containing 2
SIRT2 sirtuin 2
SKIL SKI-like proto-oncogene
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SP2 Sp2 transcription factor
STAG1 stromal antigen 1
STIP1 stress-induced phosphoprotein 1
TADA3 transcriptional adaptor 3
TDGF1 teratocarcinoma-derived growth factor 1
TLN2 talin 2
TOP1MT topoisomerase (DNA) I, mitochondrial
TXNRD1 thioredoxin reductase 1
TXNRD2 thioredoxin reductase 2
UIMC1 ubiquitin interaction motif containing 1
WASL Wiskott-Aldrich syndrome-like
YBX1 Y box binding protein 1