decreased hematopoietic stem cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages (Mammalian Phenotype Ontology, MP_0004810)
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42 gene mutations causing the decreased hematopoietic stem cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASXL1 additional sex combs like transcriptional regulator 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCR breakpoint cluster region
CBFB core-binding factor, beta subunit
CDK6 cyclin-dependent kinase 6
CREBBP CREB binding protein
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTC1 CTS telomere maintenance complex component 1
CXCL12 chemokine (C-X-C motif) ligand 12
ERCC1 excision repair cross-complementation group 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV2 ets variant 2
FLT3LG fms-related tyrosine kinase 3 ligand
FOXO3 forkhead box O3
GATA2 GATA binding protein 2
HAX1 HCLS1 associated protein X-1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6ST interleukin 6 signal transducer
JAK3 Janus kinase 3
KAT6A K(lysine) acetyltransferase 6A
KIAA0101 KIAA0101
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
LIF leukemia inhibitory factor
LIG4 ligase IV, DNA, ATP-dependent
MBTD1 mbt domain containing 1
MECOM MDS1 and EVI1 complex locus
MPL MPL proto-oncogene, thrombopoietin receptor
MSI2 musashi RNA-binding protein 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPL27A ribosomal protein L27a
RUNX1 runt-related transcription factor 1
SOX17 SRY (sex determining region Y)-box 17
SPI1 Spi-1 proto-oncogene
TACC3 transforming, acidic coiled-coil containing protein 3
TP53 tumor protein p53
ZFX zinc finger protein, X-linked