decreased incidence of tumors by chemical induction Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens (Mammalian Phenotype Ontology, MP_0004502)
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60 gene mutations causing the decreased incidence of tumors by chemical induction phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AFP alpha-fetoprotein
AGTR2 angiotensin II receptor, type 2
AHRR aryl-hydrocarbon receptor repressor
AR androgen receptor
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BRCA2 breast cancer 2, early onset
CACFD1 calcium channel flower domain containing 1
CCL13 chemokine (C-C motif) ligand 13
CD34 CD34 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DEK DEK proto-oncogene
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGF22 fibroblast growth factor 22
FOXN1 forkhead box N1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HCST hematopoietic cell signal transducer
HIPK1 homeodomain interacting protein kinase 1
HRAS Harvey rat sarcoma viral oncogene homolog
IER3 immediate early response 3
IL12B interleukin 12B
IL1R1 interleukin 1 receptor, type I
IL23A interleukin 23, alpha subunit p19
IL6 interleukin 6
IL6R interleukin 6 receptor
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MMP19 matrix metallopeptidase 19
MPG N-methylpurine-DNA glycosylase
MYD88 myeloid differentiation primary response 88
NEU3 sialidase 3 (membrane sialidase)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCE1 phospholipase C, epsilon 1
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRJ protein tyrosine phosphatase, receptor type, J
PVR poliovirus receptor
RALGDS ral guanine nucleotide dissociation stimulator
SKIL SKI-like proto-oncogene
SPP1 secreted phosphoprotein 1
STAG1 stromal antigen 1
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TP53 tumor protein p53
TREM1 triggering receptor expressed on myeloid cells 1
TRIM27 tripartite motif containing 27