decreased liver cholesterol level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues (Mammalian Phenotype Ontology, MP_0010026)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010026
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Genes

16 gene mutations causing the decreased liver cholesterol level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACOT13 acyl-CoA thioesterase 13
DGAT1 diacylglycerol O-acyltransferase 1
DHCR7 7-dehydrocholesterol reductase
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
FABP6 fatty acid binding protein 6, ileal
FOXO1 forkhead box O1
NPC1 Niemann-Pick disease, type C1
NR1D1 nuclear receptor subfamily 1, group D, member 1
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PEX2 peroxisomal biogenesis factor 2
PPARD peroxisome proliferator-activated receptor delta
SCP2 sterol carrier protein 2
SIK3 SIK family kinase 3
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SREBF2 sterol regulatory element binding transcription factor 2
STARD10 StAR-related lipid transfer (START) domain containing 10
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