decreased mast cell degranulation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell (Mammalian Phenotype Ontology, MP_0008765)
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17 gene mutations causing the decreased mast cell degranulation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA3 adenosine A3 receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GAB2 GRB2-associated binding protein 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MILR1 mast cell immunoglobulin-like receptor 1
MIR142 microRNA 142
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PLA2G3 phospholipase A2, group III
PTGDR prostaglandin D2 receptor (DP)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRC protein tyrosine phosphatase, receptor type, C
RHOH ras homolog family member H
STIM1 stromal interaction molecule 1
STXBP2 syntaxin binding protein 2
TRIB3 tribbles pseudokinase 3
VAMP8 vesicle-associated membrane protein 8