decreased mast cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description fewer than expected number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation (Mammalian Phenotype Ontology, MP_0000336)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000336
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Genes

17 gene mutations causing the decreased mast cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
C3 complement component 3
CCR1 chemokine (C-C motif) receptor 1
CD44 CD44 molecule (Indian blood group)
CPA3 carboxypeptidase A3 (mast cell)
GAB2 GRB2-associated binding protein 2
HDC histidine decarboxylase
ITGB7 integrin, beta 7
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MITF microphthalmia-associated transcription factor
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SRGN serglycin
STAT5A signal transducer and activator of transcription 5A
Funding