decreased midbrain size Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes (Mammalian Phenotype Ontology, MP_0012089)
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17 gene mutations causing the decreased midbrain size phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CCNF cyclin F
CIT citron rho-interacting serine/threonine kinase
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DKK1 dickkopf WNT signaling pathway inhibitor 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EN1 engrailed homeobox 1
ERF Ets2 repressor factor
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
LMNB1 lamin B1
OTX1 orthodenticle homeobox 1
OTX2 orthodenticle homeobox 2
RAX retina and anterior neural fold homeobox
SHH sonic hedgehog
SSBP3 single stranded DNA binding protein 3
TDGF1 teratocarcinoma-derived growth factor 1
TUBB2B tubulin, beta 2B class IIb
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)