decreased pancreatic beta cell mass Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state (Mammalian Phenotype Ontology, MP_0009114)
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22 gene mutations causing the decreased pancreatic beta cell mass phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALX3 ALX homeobox 3
BGLAP bone gamma-carboxyglutamate (gla) protein
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CD38 CD38 molecule
COL5A3 collagen, type V, alpha 3
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
GCK glucokinase (hexokinase 4)
GDF11 growth differentiation factor 11
GHR growth hormone receptor
HPRT1 hypoxanthine phosphoribosyltransferase 1
ILDR2 immunoglobulin-like domain containing receptor 2
INS insulin
IRS2 insulin receptor substrate 2
LEP leptin
MIR375 microRNA 375
MYD88 myeloid differentiation primary response 88
PDX1 pancreatic and duodenal homeobox 1
PRLR prolactin receptor
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SERTAD1 SERTA domain containing 1
SOX9 SRY (sex determining region Y)-box 9
TLR3 toll-like receptor 3