decreased pancreatic beta cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description fewer than normal number of the cells of the pancreas that secrete insulin (Mammalian Phenotype Ontology, MP_0003339)
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36 gene mutations causing the decreased pancreatic beta cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADIPOR2 adiponectin receptor 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
AQP7 aquaporin 7
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
COL5A3 collagen, type V, alpha 3
CYB5R4 cytochrome b5 reductase 4
DACH1 dachshund family transcription factor 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FGF10 fibroblast growth factor 10
GLIS3 GLIS family zinc finger 3
HNF1A HNF1 homeobox A
HPRT1 hypoxanthine phosphoribosyltransferase 1
ILDR2 immunoglobulin-like domain containing receptor 2
INS insulin
INSL5 insulin-like 5
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
LEP leptin
MIR375 microRNA 375
MNX1 motor neuron and pancreas homeobox 1
NEUROD1 neuronal differentiation 1
NEUROG3 neurogenin 3
NKX2-2 NK2 homeobox 2
NKX6-1 NK6 homeobox 1
ONECUT1 one cut homeobox 1
PAX4 paired box 4
PAX6 paired box 6
PCSK2 proprotein convertase subtilisin/kexin type 2
PDX1 pancreatic and duodenal homeobox 1
PRF1 perforin 1 (pore forming protein)
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
SEC23B Sec23 homolog B (S. cerevisiae)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SSTR5 somatostatin receptor 5
WFS1 Wolfram syndrome 1 (wolframin)