decreased pre-b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface (Mammalian Phenotype Ontology, MP_0008209)
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54 gene mutations causing the decreased pre-b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AFF1 AF4/FMR2 family, member 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
ATP11C ATPase, class VI, type 11C
BCL2 B-cell CLL/lymphoma 2
BLNK B-cell linker
CCND3 cyclin D3
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CREBBP CREB binding protein
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DKC1 dyskeratosis congenita 1, dyskerin
EWSR1 EWS RNA-binding protein 1
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
FZD9 frizzled class receptor 9
HAX1 HCLS1 associated protein X-1
HTRA2 HtrA serine peptidase 2
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
JAK3 Janus kinase 3
KAT6A K(lysine) acetyltransferase 6A
KMT2E lysine (K)-specific methyltransferase 2E
MSI2 musashi RNA-binding protein 2
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
PFDN1 prefoldin subunit 1
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD50 RAD50 homolog (S. cerevisiae)
RAG2 recombination activating gene 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SGPL1 sphingosine-1-phosphate lyase 1
SOCS1 suppressor of cytokine signaling 1
SOX4 SRY (sex determining region Y)-box 4
SPI1 Spi-1 proto-oncogene
SYK spleen tyrosine kinase
TCF12 transcription factor 12
TCF3 transcription factor 3
TET2 tet methylcytosine dioxygenase 2
TWSG1 twisted gastrulation BMP signaling modulator 1
VPREB1 pre-B lymphocyte 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6