decreased regulatory T cell number Gene Set

Dataset IMPC Knockout Mouse Phenotypes
Category disease or phenotype associations
Type phenotype
Description reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity (Mammalian Phenotype Ontology, MP_0004974)
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Genes

7 gene knockouts causing the decreased regulatory T cell number phenotype in mic from the IMPC Knockout Mouse Phenotypes dataset.

Symbol Name
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
GMDS GDP-mannose 4,6-dehydratase
NCF2 neutrophil cytosolic factor 2
PCLAF PCNA clamp associated factor
RWDD1 RWD domain containing 1
SIK3 SIK family kinase 3
TRIM56 tripartite motif containing 56