decreased regulatory T cell number Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity (Mammalian Phenotype Ontology, MP_0004974)
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Genes

45 gene mutations causing the decreased regulatory T cell number phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
AIRE autoimmune regulator
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CARD11 caspase recruitment domain family, member 11
CARMIL2 capping protein regulator and myosin 1 linker 2
CD1D CD1d molecule
CD27 CD27 molecule
CD28 CD28 molecule
CD40LG CD40 ligand
CD70 CD70 molecule
CD86 CD86 molecule
E2F1 E2F transcription factor 1
FADS1 fatty acid desaturase 1
FOXP3 forkhead box P3
GMDS GDP-mannose 4,6-dehydratase
GPR15 G protein-coupled receptor 15
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
IER3 immediate early response 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL15 interleukin 15
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
LGALS9C lectin, galactoside-binding, soluble, 9C
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARCHF1 membrane associated ring-CH-type finger 1
MIR125A microRNA 125a
MIR155 microRNA 155
MYCT1 myc target 1
NCF2 neutrophil cytosolic factor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PCLAF PCNA clamp associated factor
PDCD1 programmed cell death 1
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
RWDD1 RWD domain containing 1
SIK3 SIK family kinase 3
TESPA1 thymocyte expressed, positive selection associated 1
THBS1 thrombospondin 1
THEMIS thymocyte selection associated
TRAF3IP3 TRAF3 interacting protein 3
TRIM56 tripartite motif containing 56
USP17L8 ubiquitin specific peptidase 17-like family member 8
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XCL2 chemokine (C motif) ligand 2
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF335 zinc finger protein 335