decreased regulatory t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity (Mammalian Phenotype Ontology, MP_0004974)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004974
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Genes

38 gene mutations causing the decreased regulatory t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
ARL4D ADP-ribosylation factor-like 4D
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
CARD11 caspase recruitment domain family, member 11
CD1D CD1d molecule
CD27 CD27 molecule
CD28 CD28 molecule
CD40LG CD40 ligand
CD70 CD70 molecule
CD86 CD86 molecule
E2F1 E2F transcription factor 1
FADS1 fatty acid desaturase 1
FOXP3 forkhead box P3
GPR15 G protein-coupled receptor 15
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL15 interleukin 15
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
LGALS9B lectin, galactoside-binding, soluble, 9B
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MIR155 microRNA 155
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDCD1 programmed cell death 1
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
SGOL1 shugoshin-like 1 (S. pombe)
TESPA1 thymocyte expressed, positive selection associated 1
THBS1 thrombospondin 1
THEMIS thymocyte selection associated
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XCL1 chemokine (C motif) ligand 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF335 zinc finger protein 335