decreased susceptibility to infection induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens (Mammalian Phenotype Ontology, MP_0009786)
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61 gene mutations causing the decreased susceptibility to infection induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ANK1 ankyrin 1, erythrocytic
ANTXR2 anthrax toxin receptor 2
APCS amyloid P component, serum
CASP12 caspase 12 (gene/pseudogene)
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD200R1 CD200 receptor 1
CD274 CD274 molecule
CD47 CD47 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CTSG cathepsin G
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CYLD cylindromatosis (turban tumor syndrome)
ELANE elastase, neutrophil expressed
FCMR Fc fragment of IgM receptor
FGL2 fibrinogen-like 2
GUCY2C guanylate cyclase 2C
HAVCR2 hepatitis A virus cellular receptor 2
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL13 interleukin 13
IL15 interleukin 15
IL1B interleukin 1, beta
IL6R interleukin 6 receptor
JAK3 Janus kinase 3
JCHAIN joining chain of multimeric IgA and IgM
KHSRP KH-type splicing regulatory protein
KLRK1 killer cell lectin-like receptor subfamily K, member 1
MMP9 matrix metallopeptidase 9
MRC1 mannose receptor, C type 1
MX1 MX dynamin-like GTPase 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NCR1 natural cytotoxicity triggering receptor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OASL 2'-5'-oligoadenylate synthetase-like
OTUD7B OTU deubiquitinase 7B
PELI3 pellino E3 ubiquitin protein ligase family member 3
PGLYRP2 peptidoglycan recognition protein 2
PIAS1 protein inhibitor of activated STAT, 1
PILRB paired immunoglobin-like type 2 receptor beta
PKLR pyruvate kinase, liver and RBC
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAG2 recombination activating gene 2
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SOCS1 suppressor of cytokine signaling 1
SPP1 secreted phosphoprotein 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TERF2IP telomeric repeat binding factor 2, interacting protein
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP21 ubiquitin specific peptidase 21
VTCN1 V-set domain containing T cell activation inhibitor 1