decreased susceptibility to ischemic brain injury Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of all or part of the brain tissue, compared to controls (Mammalian Phenotype Ontology, MP_0006059)
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36 gene mutations causing the decreased susceptibility to ischemic brain injury phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2A adenosine A2a receptor
APOE apolipoprotein E
AQP4 aquaporin 4
C3 complement component 3
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CST3 cystatin C
CX3CL1 chemokine (C-X3-C motif) ligand 1
DAPK1 death-associated protein kinase 1
EGR1 early growth response 1
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GPX3 glutathione peroxidase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IL18 interleukin 18
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MMP9 matrix metallopeptidase 9
NBEAL2 neurobeachin-like 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOX4 NADPH oxidase 4
OLFM1 olfactomedin 1
PANX2 pannexin 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLD1 phospholipase D1, phosphatidylcholine-specific
PPIF peptidylprolyl isomerase F
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SNTA1 syntrophin, alpha 1
STIM2 stromal interaction molecule 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWF von Willebrand factor