decreased susceptibility to pharmacologically induced seizures Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals; exhibit a higher threshold to induce seizure activity (Mammalian Phenotype Ontology, MP_0002887)
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26 gene mutations causing the decreased susceptibility to pharmacologically induced seizures phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKAP5 A kinase (PRKA) anchor protein 5
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CKB creatine kinase, brain
CLCN3 chloride channel, voltage-sensitive 3
FGF22 fibroblast growth factor 22
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM5 glutamate receptor, metabotropic 5
JUN jun proto-oncogene
MAPK10 mitogen-activated protein kinase 10
MAPT microtubule-associated protein tau
NPY neuropeptide Y
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PANX1 pannexin 1
PPP1R9B protein phosphatase 1, regulatory subunit 9B
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SEZ6 seizure related 6 homolog (mouse)
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
TRIM3 tripartite motif containing 3
TRPC5 transient receptor potential cation channel, subfamily C, member 5