defense Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

309 genes co-occuring with the biological term defense in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM17 ADAM metallopeptidase domain 17
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
AHR aryl hydrocarbon receptor
AICDA activation-induced cytidine deaminase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
ALPI alkaline phosphatase, intestinal
AMBP alpha-1-microglobulin/bikunin precursor
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPT1 angiopoietin 1
APCS amyloid P component, serum
APOB apolipoprotein B
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOD apolipoprotein D
APOE apolipoprotein E
AQP2 aquaporin 2 (collecting duct)
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKA aurora kinase A
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BECN1 beclin 1, autophagy related
BPI bactericidal/permeability-increasing protein
BPIFA1 BPI fold containing family A, member 1
BST2 bone marrow stromal cell antigen 2
C1QA complement component 1, q subcomponent, A chain
CAMP cathelicidin antimicrobial peptide
CASP12 caspase 12 (gene/pseudogene)
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CCL1 chemokine (C-C motif) ligand 1
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD163 CD163 molecule
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFH complement factor H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLEC7A C-type lectin domain family 7, member A
COLEC11 collectin sub-family member 11
CP ceruloplasmin (ferroxidase)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB1 cAMP responsive element binding protein 1
CRISP3 cysteine-rich secretory protein 3
CRP C-reactive protein, pentraxin-related
CRYAB crystallin, alpha B
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSD cathepsin D
CTSE cathepsin E
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAXX death-domain associated protein
DCD dermcidin
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFB1 defensin, beta 1
DEFB103A defensin, beta 103A
DEFB103B defensin, beta 103B
DEFB104A defensin, beta 104A
DEFB104B defensin, beta 104B
DEFB4A defensin, beta 4A
DICER1 dicer 1, ribonuclease type III
DMBT1 deleted in malignant brain tumors 1
DUOX1 dual oxidase 1
DUOX2 dual oxidase 2
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
FANCD2 Fanconi anemia, complementation group D2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FLG filaggrin
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FUBP1 far upstream element (FUSE) binding protein 1
FXYD3 FXYD domain containing ion transport regulator 3
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBP1 guanylate binding protein 1, interferon-inducible
GLS2 glutaminase 2 (liver, mitochondrial)
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GSTA4 glutathione S-transferase alpha 4
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AFX H2A histone family, member X
HAMP hepcidin antimicrobial peptide
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H2BC histone cluster 1, H2bc
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BI histone cluster 1, H2bi
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HNF4A hepatocyte nuclear factor 4, alpha
HSF1 heat shock transcription factor 1
HSPA1B heat shock 70kDa protein 1B
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB2 heat shock 27kDa protein 2
HTT huntingtin
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI16 interferon, gamma-inducible protein 16
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA2 interferon, alpha 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IGH immunoglobulin heavy locus
IL10 interleukin 10
IL15 interleukin 15
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL22 interleukin 22
IL27 interleukin 27
IL32 interleukin 32
IL33 interleukin 33
IL33R interleukin 33 receptor
IL36B interleukin 36, beta
IL6 interleukin 6
ILF3 interleukin enhancer binding factor 3, 90kDa
IQGAP1 IQ motif containing GTPase activating protein 1
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
IRF6 interferon regulatory factor 6
IRG1 immunoresponsive 1 homolog (mouse)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITLN1 intelectin 1 (galactofuranose binding)
JAK1 Janus kinase 1
KEAP1 kelch-like ECH-associated protein 1
KLK13 kallikrein-related peptidase 13
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
KLRC2 killer cell lectin-like receptor subfamily C, member 2
LAMA4 laminin, alpha 4
LAMA5 laminin, alpha 5
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LIAS lipoic acid synthetase
LPO lactoperoxidase
LRP1 low density lipoprotein receptor-related protein 1
LTF lactotransferrin
LYZL2 lysozyme-like 2
MAPK14 mitogen-activated protein kinase 14
MARCO macrophage receptor with collagenous structure
MBL2 mannose-binding lectin (protein C) 2, soluble
MCAM melanoma cell adhesion molecule
MDK midkine (neurite growth-promoting factor 2)
MIR328 microRNA 328
MIR424 microRNA 424
MIR503 microRNA 503
MIR762 microRNA 762
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MRC1 mannose receptor, C type 1
MSRA methionine sulfoxide reductase A
MT-ATP6 ATP synthase F0 subunit 6
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
NAIP NLR family, apoptosis inhibitory protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NCAM1 neural cell adhesion molecule 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRC4 NLR family, CARD domain containing 4
NLRC5 NLR family, CARD domain containing 5
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NNT nicotinamide nucleotide transhydrogenase
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRIP1 nuclear receptor interacting protein 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5
NUP98 nucleoporin 98kDa
NUPR1 nuclear protein, transcriptional regulator, 1
NXNL1 nucleoredoxin-like 1
ODC1 ornithine decarboxylase 1
OIT3 oncoprotein induced transcript 3
OLFM4 olfactomedin 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PI3 peptidase inhibitor 3, skin-derived
PIGR polymeric immunoglobulin receptor
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRF1 perforin 1 (pore forming protein)
PRMT5 protein arginine methyltransferase 5
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PXDN peroxidasin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIPK2 receptor-interacting serine-threonine kinase 2
RNASE7 ribonuclease, RNase A family, 7
RNASE9 ribonuclease, RNase A family, 9 (non-active)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S1PR1 sphingosine-1-phosphate receptor 1
SCARB1 scavenger receptor class B, member 1
SCP2 sterol carrier protein 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SESN3 sestrin 3
SFTPA1 surfactant protein A1
SFTPA2 surfactant protein A2
SFTPD surfactant protein D
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLPI secretory leukocyte peptidase inhibitor
SOD1 superoxide dismutase 1, soluble
SOD3 superoxide dismutase 3, extracellular
SP1 Sp1 transcription factor
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STATH statherin
TAS2R38 taste receptor, type 2, member 38
TERT telomerase reverse transcriptase
TFF2 trefoil factor 2
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
THBS1 thrombospondin 1
THOP1 thimet oligopeptidase 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TMEM173 transmembrane protein 173
TMX1 thioredoxin-related transmembrane protein 1
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRDMT1 tRNA aspartic acid methyltransferase 1
TREM1 triggering receptor expressed on myeloid cells 1
TREM2 triggering receptor expressed on myeloid cells 2
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TUBB4A tubulin, beta 4A class IVa
TXN thioredoxin
TXN2 thioredoxin 2
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)
TXNRD1 thioredoxin reductase 1
UMOD uromodulin
XDH xanthine dehydrogenase
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZC3H12A zinc finger CCCH-type containing 12A