deficient Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

395 genes co-occuring with the biological term deficient in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ABHD5 abhydrolase domain containing 5
ACVR1 activin A receptor, type I
ADAM12 ADAM metallopeptidase domain 12
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AHR aryl hydrocarbon receptor
AHSG alpha-2-HS-glycoprotein
AIM2 absent in melanoma 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX12 arachidonate 12-lipoxygenase
ALOX12B arachidonate 12-lipoxygenase, 12R type
ANXA7 annexin A7
APAF1 apoptotic peptidase activating factor 1
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOE apolipoprotein E
APRT adenine phosphoribosyltransferase
APTX aprataxin
ARID1A AT rich interactive domain 1A (SWI-like)
ARRB2 arrestin, beta 2
ARSA arylsulfatase A
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BAIAP2 BAI1-associated protein 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BDNF brain-derived neurotrophic factor
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRCA1 breast cancer 1, early onset
BRMS1 breast cancer metastasis suppressor 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
C5 complement component 5
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CALCRL calcitonin receptor-like
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARTPT CART prepropeptide
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CCNL2 cyclin L2
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD19 CD19 molecule
CD1D CD1d molecule
CD24 CD24 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK10 cyclin-dependent kinase 10
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
CETP cholesteryl ester transfer protein, plasma
CFD complement factor D (adipsin)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK2 checkpoint kinase 2
CLDN5 claudin 5
COA5 cytochrome c oxidase assembly factor 5
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSB cathepsin B
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYTH2 cytohesin 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DCXR dicarbonyl/L-xylulose reductase
DDB2 damage-specific DNA binding protein 2, 48kDa
DEFB103B defensin, beta 103B
DHODH dihydroorotate dehydrogenase (quinone)
DKC1 dyskeratosis congenita 1, dyskerin
DMD dystrophin
DNM1L dynamin 1-like
DPP4 dipeptidyl-peptidase 4
DPYD dihydropyrimidine dehydrogenase
DRD2 dopamine receptor D2
DROSHA drosha, ribonuclease type III
DYSF dysferlin
EBI3 Epstein-Barr virus induced 3
EDN1 endothelin 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EMD emerin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC4 excision repair cross-complementation group 4
ERCC6 excision repair cross-complementation group 6
ESR2 estrogen receptor 2 (ER beta)
ETV6 ets variant 6
F11 coagulation factor XI
F13A1 coagulation factor XIII, A1 polypeptide
F2RL2 coagulation factor II (thrombin) receptor-like 2
F5 coagulation factor V (proaccelerin, labile factor)
F9 coagulation factor IX
FANCC Fanconi anemia, complementation group C
FAS Fas cell surface death receptor
FGF23 fibroblast growth factor 23
FH fumarate hydratase
FLCN folliculin
FLG filaggrin
FTL ferritin, light polypeptide
FUT2 fucosyltransferase 2 (secretor status included)
FXN frataxin
G6PD glucose-6-phosphate dehydrogenase
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45B growth arrest and DNA-damage-inducible, beta
GAMT guanidinoacetate N-methyltransferase
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GBA glucosidase, beta, acid
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCG glucagon
GFI1 growth factor independent 1 transcription repressor
GH1 growth hormone 1
GHR growth hormone receptor
GIF gastric intrinsic factor (vitamin B synthesis)
GLA galactosidase, alpha
GLB1 galactosidase, beta 1
GRB2 growth factor receptor-bound protein 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAMP hepcidin antimicrobial peptide
HBA2 hemoglobin, alpha 2
HBB hemoglobin, beta
HCCS holocytochrome c synthase
HCRT hypocretin (orexin) neuropeptide precursor
HDAC2 histone deacetylase 2
HDAC7 histone deacetylase 7
HEXA hexosaminidase A (alpha polypeptide)
HGD homogentisate 1,2-dioxygenase
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HOXA11 homeobox A11
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTRA2 HtrA serine peptidase 2
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL15 interleukin 15
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL27 interleukin 27
IL4 interleukin 4
IL6 interleukin 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNK2 potassium channel, two pore domain subfamily K, member 2
KDM8 lysine (K)-specific demethylase 8
KEL Kell blood group, metallo-endopeptidase
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF2C kinesin family member 2C
KRAS Kirsten rat sarcoma viral oncogene homolog
LACRT lacritin
LAMA2 laminin, alpha 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP2 lysosomal-associated membrane protein 2
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LEPQTL1 Leptin, serum levels of
LGALS3 lectin, galactoside-binding, soluble, 3
LHCGR luteinizing hormone/choriogonadotropin receptor
LIG4 ligase IV, DNA, ATP-dependent
LIPC lipase, hepatic
LMNA lamin A/C
LRP1 low density lipoprotein receptor-related protein 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY96 lymphocyte antigen 96
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MBL2 mannose-binding lectin (protein C) 2, soluble
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEPE matrix extracellular phosphoglycoprotein
MFN2 mitofusin 2
MGMT O-6-methylguanine-DNA methyltransferase
MIR133B microRNA 133b
MLH1 mutL homolog 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
MRC2 mannose receptor, C type 2
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MT2A metallothionein 2A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC16 mucin 16, cell surface associated
MYD88 myeloid differentiation primary response 88
NABP2 nucleic acid binding protein 2
NBN nibrin
NCF1 neutrophil cytosolic factor 1
NDRG1 N-myc downstream regulated 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
OCTN3 organic cation transporter 3
OGG1 8-oxoguanine DNA glycosylase
OXSR1 oxidative stress responsive 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PAX5 paired box 5
PAX6 paired box 6
PCBP1 poly(rC) binding protein 1
PCBP2 poly(rC) binding protein 2
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDGFB platelet-derived growth factor beta polypeptide
PIGM phosphatidylinositol glycan anchor biosynthesis, class M
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PINK1 PTEN induced putative kinase 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKLR pyruvate kinase, liver and RBC
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEC plectin
PLTP phospholipid transfer protein
PMM2 phosphomannomutase 2
PNP purine nucleoside phosphorylase
PNPLA2 patatin-like phospholipase domain containing 2
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
PPARG peroxisome proliferator-activated receptor gamma
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRDM1 PR domain containing 1, with ZNF domain
PRDM2 PR domain containing 2, with ZNF domain
PRKCD protein kinase C, delta
PRM2 protamine 2
PRNP prion protein
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROS1 protein S (alpha)
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PVR poliovirus receptor
PXN paxillin
PYCARD PYD and CARD domain containing
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RAG2 recombination activating gene 2
RBM8A RNA binding motif protein 8A
RCOR1 REST corepressor 1
RECQL4 RecQ protein-like 4
REST RE1-silencing transcription factor
RGR retinal G protein coupled receptor
RPH3A rabphilin 3A
RPS6 ribosomal protein S6
SCO2 SCO2 cytochrome c oxidase assembly protein
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SECISBP2 SECIS binding protein 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMN1 survival of motor neuron 1, telomeric
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX12 sorting nexin 12
SOAT2 sterol O-acyltransferase 2
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRSF1 serine/arginine-rich splicing factor 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STX11 syntaxin 11
STX1A syntaxin 1A (brain)
SYK spleen tyrosine kinase
TACR1 tachykinin receptor 1
TARBP2 TAR (HIV-1) RNA binding protein 2
TCF3 transcription factor 3
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TFF3 trefoil factor 3 (intestinal)
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TLN1 talin 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP73 tumor protein p73
TPH2 tryptophan hydroxylase 2
TPI1 triosephosphate isomerase 1
TPMT thiopurine S-methyltransferase
TPP1 tripeptidyl peptidase I
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TTN titin
TYMS thymidylate synthetase
TYROBP TYRO protein tyrosine kinase binding protein
UBE3A ubiquitin protein ligase E3A
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UPB1 ureidopropionase, beta
UTRN utrophin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIPR1 vasoactive intestinal peptide receptor 1
WNK1 WNK lysine deficient protein kinase 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa