demecarium bromide-2773 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the demecarium bromide-2773 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APAF1 apoptotic peptidase activating factor 1
APOLD1 apolipoprotein L domain containing 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARFRP1 ADP-ribosylation factor related protein 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BTF3P11 basic transcription factor 3 pseudogene 11
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF79 chromosome 14 open reading frame 79
C14ORF93 chromosome 14 open reading frame 93
C1ORF61 chromosome 1 open reading frame 61
C21ORF2 chromosome 21 open reading frame 2
CADM3 cell adhesion molecule 3
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CARTPT CART prepropeptide
CD58 CD58 molecule
CD7 CD7 molecule
CES3 carboxylesterase 3
CFP complement factor properdin
COL1A1 collagen, type I, alpha 1
COL7A1 collagen, type VII, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CREM cAMP responsive element modulator
CRMP1 collapsin response mediator protein 1
CXXC4 CXXC finger protein 4
CYLD cylindromatosis (turban tumor syndrome)
DAPK2 death-associated protein kinase 2
DCAF15 DDB1 and CUL4 associated factor 15
DST dystonin
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ETV5 ets variant 5
FAM63B family with sequence similarity 63, member B
FBXL7 F-box and leucine-rich repeat protein 7
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GM2A GM2 ganglioside activator
GMPR guanosine monophosphate reductase
HBP1 HMG-box transcription factor 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIST2H2AA3 histone cluster 2, H2aa3
HOXB5 homeobox B5
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQSEC2 IQ motif and Sec7 domain 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLHL18 kelch-like family member 18
KLHL22 kelch-like family member 22
KLRG1 killer cell lectin-like receptor subfamily G, member 1
MAP4 microtubule-associated protein 4
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD2 methyl-CpG binding domain protein 2
MBNL2 muscleblind-like splicing regulator 2
MMP25 matrix metallopeptidase 25
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MZT2B mitotic spindle organizing protein 2B
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NF1 neurofibromin 1
NME5 NME/NM23 family member 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAWR PRKC, apoptosis, WT1, regulator
PDZK1IP1 PDZK1 interacting protein 1
PLTP phospholipid transfer protein
PML promyelocytic leukemia
POU4F1 POU class 4 homeobox 1
PRSS53 protease, serine, 53
PTPRE protein tyrosine phosphatase, receptor type, E
QTRT1 queuine tRNA-ribosyltransferase 1
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RFXAP regulatory factor X-associated protein
SIRT5 sirtuin 5
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPEG SPEG complex locus
SPPL2B signal peptide peptidase like 2B
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TGFBR1 transforming growth factor, beta receptor 1
THRB thyroid hormone receptor, beta
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM3 tropomyosin 3
TRIM29 tripartite motif containing 29
TRIM62 tripartite motif containing 62
TTLL4 tubulin tyrosine ligase-like family member 4
TULP1 tubby like protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZC3H7B zinc finger CCCH-type containing 7B
ZEB1 zinc finger E-box binding homeobox 1
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
ALDOC aldolase C, fructose-bisphosphate
ANXA2P3 annexin A2 pseudogene 3
BMP4 bone morphogenetic protein 4
C2ORF54 chromosome 2 open reading frame 54
C5AR2 complement component 5a receptor 2
CA11 carbonic anhydrase XI
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CCDC132 coiled-coil domain containing 132
CCDC186 coiled-coil domain containing 186
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD3EAP CD3e molecule, epsilon associated protein
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIC capicua transcriptional repressor
CLCN5 chloride channel, voltage-sensitive 5
CLSPN claspin
CPTP ceramide-1-phosphate transfer protein
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFCAB2 EF-hand calcium binding domain 2
EFNA1 ephrin-A1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
FAM188A family with sequence similarity 188, member A
FAM212B family with sequence similarity 212, member B
FAM50B family with sequence similarity 50, member B
FAM76A family with sequence similarity 76, member A
FBXL6 F-box and leucine-rich repeat protein 6
FGD1 FYVE, RhoGEF and PH domain containing 1
FGL1 fibrinogen-like 1
FKBP10 FK506 binding protein 10, 65 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
GATA4 GATA binding protein 4
GBP2 guanylate binding protein 2, interferon-inducible
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLI3 GLI family zinc finger 3
GNA12 guanine nucleotide binding protein (G protein) alpha 12
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXA4 homeobox A4
HOXC5 homeobox C5
HYI hydroxypyruvate isomerase (putative)
IL4R interleukin 4 receptor
LARP6 La ribonucleoprotein domain family, member 6
LINC00339 long intergenic non-protein coding RNA 339
LRP5 low density lipoprotein receptor-related protein 5
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAN2C1 mannosidase, alpha, class 2C, member 1
MATK megakaryocyte-associated tyrosine kinase
MBNL3 muscleblind-like splicing regulator 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MGC12488
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MYL5 myosin, light chain 5, regulatory
NCS1 neuronal calcium sensor 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOL12 nucleolar protein 12
ONECUT2 one cut homeobox 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSMR oncostatin M receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLA2G10 phospholipase A2, group X
PLEKHO2 pleckstrin homology domain containing, family O member 2
POMT2 protein-O-mannosyltransferase 2
PROS1 protein S (alpha)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRSS16 protease, serine, 16 (thymus)
PTK6 protein tyrosine kinase 6
RABL6 RAB, member RAS oncogene family-like 6
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFTN1 raftlin, lipid raft linker 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF43 ring finger protein 43
RPUSD2 RNA pseudouridylate synthase domain containing 2
SIX1 SIX homeobox 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMIM14 small integral membrane protein 14
SND1-IT1 SND1 intronic transcript 1
SPIDR scaffolding protein involved in DNA repair
STAG3 stromal antigen 3
STON1 stonin 1
TBC1D17 TBC1 domain family, member 17
TCTN2 tectonic family member 2
TRABD TraB domain containing
TTBK2 tau tubulin kinase 2
USP6NL USP6 N-terminal like
VEZT vezatin, adherens junctions transmembrane protein
VGF VGF nerve growth factor inducible
ZBTB48 zinc finger and BTB domain containing 48
ZNF34 zinc finger protein 34
ZNF365 zinc finger protein 365
ZSCAN31 zinc finger and SCAN domain containing 31