demeclocycline-2545 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the demeclocycline-2545 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACRV1 acrosomal vesicle protein 1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AQP9 aquaporin 9
ARMCX4 armadillo repeat containing, X-linked 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BEST1 bestrophin 1
BTF3P11 basic transcription factor 3 pseudogene 11
BTG2 BTG family, member 2
C11ORF16 chromosome 11 open reading frame 16
C1RL complement component 1, r subcomponent-like
C21ORF2 chromosome 21 open reading frame 2
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CD52 CD52 molecule
CD6 CD6 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHN1 chimerin 1
CLCN4 chloride channel, voltage-sensitive 4
COL14A1 collagen, type XIV, alpha 1
COL6A1 collagen, type VI, alpha 1
COPE coatomer protein complex, subunit epsilon
COQ6 coenzyme Q6 monooxygenase
CPED1 cadherin-like and PC-esterase domain containing 1
CSNK1G1 casein kinase 1, gamma 1
CTAGE9 CTAGE family, member 9
CTBP2 C-terminal binding protein 2
DCN decorin
DGKG diacylglycerol kinase, gamma 90kDa
DLL3 delta-like 3 (Drosophila)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DSCAM Down syndrome cell adhesion molecule
ESR1 estrogen receptor 1
FGF21 fibroblast growth factor 21
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLJ11292
FYB FYN binding protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GATA6 GATA binding protein 6
GH2 growth hormone 2
GOSR2 golgi SNAP receptor complex member 2
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
HDGFRP3 hepatoma-derived growth factor, related protein 3
ICOSLG inducible T-cell co-stimulator ligand
IGH immunoglobulin heavy locus
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLF12 Kruppel-like factor 12
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LARP7 La ribonucleoprotein domain family, member 7
LHFPL2 lipoma HMGIC fusion partner-like 2
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
MAP4 microtubule-associated protein 4
MB myoglobin
MED25 mediator complex subunit 25
METTL7A methyltransferase like 7A
MILR1 mast cell immunoglobulin-like receptor 1
MX1 MX dynamin-like GTPase 1
NEFM neurofilament, medium polypeptide
NIPAL3 NIPA-like domain containing 3
NPY4R neuropeptide Y receptor Y4
OXTR oxytocin receptor
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PDE12 phosphodiesterase 12
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PLVAP plasmalemma vesicle associated protein
PRB1 proline-rich protein BstNI subfamily 1
PROL1 proline rich, lacrimal 1
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGDR2 prostaglandin D2 receptor 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAD51B RAD51 paralog B
RIMBP2 RIMS binding protein 2
RNASE3 ribonuclease, RNase A family, 3
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAS related RAS viral (r-ras) oncogene homolog
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SKIL SKI-like proto-oncogene
SLC16A6 solute carrier family 16, member 6
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TBXA2R thromboxane A2 receptor
TEF thyrotrophic embryonic factor
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TJAP1 tight junction associated protein 1 (peripheral)
TMEM63A transmembrane protein 63A
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNXB tenascin XB
WNT8B wingless-type MMTV integration site family, member 8B
XYLB xylulokinase homolog (H. influenzae)
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF155 zinc finger protein 155
ZNF287 zinc finger protein 287
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ATAD5 ATPase family, AAA domain containing 5
ATAT1 alpha tubulin acetyltransferase 1
AXIN1 axin 1
BAG3 BCL2-associated athanogene 3
BCORL1 BCL6 corepressor-like 1
BHLHE41 basic helix-loop-helix family, member e41
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
C8ORF44 chromosome 8 open reading frame 44
CCDC176 coiled-coil domain containing 176
CD3D CD3d molecule, delta (CD3-TCR complex)
CENPT centromere protein T
CEP97 centrosomal protein 97kDa
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRYZ crystallin, zeta (quinone reductase)
CTPS2 CTP synthase 2
DOK3 docking protein 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM172A family with sequence similarity 172, member A
FAM50B family with sequence similarity 50, member B
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GSDMD gasdermin D
HAL histidine ammonia-lyase
HCFC2 host cell factor C2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIRA histone cell cycle regulator
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IGKV3-20 immunoglobulin kappa variable 3-20
IL12RB1 interleukin 12 receptor, beta 1
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA0319L KIAA0319-like
KIAA1024 KIAA1024
KIF17 kinesin family member 17
LINC00260 long intergenic non-protein coding RNA 260
LOXL3 lysyl oxidase-like 3
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP5 low density lipoprotein receptor-related protein 5
LRRC20 leucine rich repeat containing 20
MAP6D1 MAP6 domain containing 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
METRN meteorin, glial cell differentiation regulator
MRPL44 mitochondrial ribosomal protein L44
NCKAP1L NCK-associated protein 1-like
NKX3-2 NK3 homeobox 2
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NSUN6 NOP2/Sun domain family, member 6
PARG poly (ADP-ribose) glycohydrolase
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PITRM1 pitrilysin metallopeptidase 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRR7 proline rich 7 (synaptic)
PTGES2 prostaglandin E synthase 2
PWAR5 Prader Willi/Angelman region RNA 5
RBM47 RNA binding motif protein 47
RFPL1S RFPL1 antisense RNA 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SERINC5 serine incorporator 5
SHPK sedoheptulokinase
SIDT1 SID1 transmembrane family, member 1
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC38A6 solute carrier family 38, member 6
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRD5A3 steroid 5 alpha-reductase 3
STBD1 starch binding domain 1
SV2A synaptic vesicle glycoprotein 2A
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM110 transmembrane protein 110
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TNNT1 troponin T type 1 (skeletal, slow)
TRAF2 TNF receptor-associated factor 2
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPAN13 tetraspanin 13
TXLNG taxilin gamma
UCN urocortin
UPK3A uroplakin 3A
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFB vascular endothelial growth factor B
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF280A zinc finger protein 280A
ZNF408 zinc finger protein 408
ZNF665 zinc finger protein 665
ZNF76 zinc finger protein 76