demeclocycline-3404 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the demeclocycline-3404 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADM adrenomedullin
AFAP1 actin filament associated protein 1
AMPD1 adenosine monophosphate deaminase 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOC1 apolipoprotein C-I
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BRAP BRCA1 associated protein
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C19ORF73 chromosome 19 open reading frame 73
C1ORF56 chromosome 1 open reading frame 56
C9ORF9 chromosome 9 open reading frame 9
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC132 coiled-coil domain containing 132
CCPG1 cell cycle progression 1
CD22 CD22 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CLSTN2 calsyntenin 2
CPNE7 copine VII
DOCK5 dedicator of cytokinesis 5
DUSP1 dual specificity phosphatase 1
EIF1 eukaryotic translation initiation factor 1
EPOR erythropoietin receptor
EXPH5 exophilin 5
FCMR Fc fragment of IgM receptor
FDPS farnesyl diphosphate synthase
FHL1 four and a half LIM domains 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GPATCH3 G patch domain containing 3
HBS1L HBS1-like translational GTPase
HIPK2 homeodomain interacting protein kinase 2
HIST1H4D histone cluster 1, H4d
IGFBP5 insulin-like growth factor binding protein 5
IPO9 importin 9
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KHSRP KH-type splicing regulatory protein
KITLG KIT ligand
LEPR leptin receptor
LIMCH1 LIM and calponin homology domains 1
LMF2 lipase maturation factor 2
LUZP1 leucine zipper protein 1
MAGEA3 melanoma antigen family A3
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MBNL3 muscleblind-like splicing regulator 3
MCM3AP minichromosome maintenance complex component 3 associated protein
NADK NAD kinase
NDRG2 NDRG family member 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDE8B phosphodiesterase 8B
PER3 period circadian clock 3
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLAGL1 pleiomorphic adenoma gene-like 1
PPAP2B phosphatidic acid phosphatase type 2B
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PTPRA protein tyrosine phosphatase, receptor type, A
RAB3D RAB3D, member RAS oncogene family
RFXAP regulatory factor X-associated protein
RNF43 ring finger protein 43
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCHIP1 schwannomin interacting protein 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35E2 solute carrier family 35, member E2
SPG20 spastic paraplegia 20 (Troyer syndrome)
ST5 suppression of tumorigenicity 5
TADA2A transcriptional adaptor 2A
TBX19 T-box 19
TBX6 T-box 6
TFPI2 tissue factor pathway inhibitor 2
TLR2 toll-like receptor 2
TSC22D4 TSC22 domain family, member 4
TTC28 tetratricopeptide repeat domain 28
TTLL3 tubulin tyrosine ligase-like family member 3
UBE2I ubiquitin-conjugating enzyme E2I
UPK3B uroplakin 3B
USB1 U6 snRNA biogenesis 1
UTRN utrophin
VGF VGF nerve growth factor inducible
XAF1 XIAP associated factor 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YY2 YY2 transcription factor
ZMAT5 zinc finger, matrin-type 5
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF329 zinc finger protein 329
ZNF423 zinc finger protein 423
ZNF646 zinc finger protein 646
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ADRA2C adrenoceptor alpha 2C
ALAS1 5'-aminolevulinate synthase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ATAD5 ATPase family, AAA domain containing 5
ATP13A2 ATPase type 13A2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL9 B-cell CLL/lymphoma 9
C16ORF59 chromosome 16 open reading frame 59
C19ORF40 chromosome 19 open reading frame 40
CAPG capping protein (actin filament), gelsolin-like
CEP131 centrosomal protein 131kDa
CFD complement factor D (adipsin)
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CINP cyclin-dependent kinase 2 interacting protein
CIR1 corepressor interacting with RBPJ, 1
CLASRP CLK4-associating serine/arginine rich protein
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CSPP1 centrosome and spindle pole associated protein 1
CTDNEP1 CTD nuclear envelope phosphatase 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DNM1 dynamin 1
EDC4 enhancer of mRNA decapping 4
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC4 excision repair cross-complementation group 4
FAM192A family with sequence similarity 192, member A
FANCE Fanconi anemia, complementation group E
FBXL12 F-box and leucine-rich repeat protein 12
FBXL2 F-box and leucine-rich repeat protein 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALK1 galactokinase 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPHN gephyrin
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HELZ helicase with zinc finger
HIST1H1D histone cluster 1, H1d
HOOK1 hook microtubule-tethering protein 1
IGSF1 immunoglobulin superfamily, member 1
ITPKC inositol-trisphosphate 3-kinase C
KREMEN2 kringle containing transmembrane protein 2
KRT13 keratin 13, type I
LIN7A lin-7 homolog A (C. elegans)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LZTR1 leucine-zipper-like transcription regulator 1
MAPK12 mitogen-activated protein kinase 12
MTMR11 myotubularin related protein 11
MTMR12 myotubularin related protein 12
NABP2 nucleic acid binding protein 2
NFE2L3 nuclear factor, erythroid 2-like 3
NT5DC3 5'-nucleotidase domain containing 3
PTK6 protein tyrosine kinase 6
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RPGR retinitis pigmentosa GTPase regulator
RPL13P5 ribosomal protein L13 pseudogene 5
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SAV1 salvador family WW domain containing protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNORA21 small nucleolar RNA, H/ACA box 21
SPATA2L spermatogenesis associated 2-like
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TESK1 testis-specific kinase 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM254 transmembrane protein 254
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNS2 tensin 2
TRAIP TRAF interacting protein
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTC9 tetratricopeptide repeat domain 9
UBQLN4 ubiquilin 4
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF134 zinc finger protein 134
ZNF189 zinc finger protein 189
ZNF365 zinc finger protein 365
ZNF408 zinc finger protein 408
ZNF623 zinc finger protein 623
ZNF652 zinc finger protein 652
ZNF862 zinc finger protein 862