dementia Gene Set

Dataset	DISEASES Curated Gene-Disease Association Evidence Scores
Category	disease or phenotype associations
Type	disease
Description	An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. (Experimental Factor Ontology, EFO_0003862)
Similar Terms
Downloads & Tools

Genes

14 genes involed in the disease dementia from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.

Symbol	Name
ADAM10	ADAM metallopeptidase domain 10
APOE	apolipoprotein E
APP	amyloid beta (A4) precursor protein
CTSD	cathepsin D
GSK3A	glycogen synthase kinase 3 alpha
GSK3B	glycogen synthase kinase 3 beta
MAPT	microtubule-associated protein tau
PLD3	phospholipase D family, member 3
PPP5C	protein phosphatase 5, catalytic subunit
PSEN1	presenilin 1
PSEN2	presenilin 2
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2
SNCA	synuclein, alpha (non A4 component of amyloid precursor)
SORL1	sortilin-related receptor, L(DLR class) A repeats containing