dental caries Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp. The three most prominent theories used to explain the etiology of the disease are that acids produced by bacteria lead to decalcification; that micro-organisms destroy the enamel protein; or that keratolytic micro-organisms produce chelates that lead to decalcification. (Experimental Factor Ontology, EFO_0003819)
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Genes

49 genes associated with the disease dental caries in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
LYZL2 lysozyme-like 2 0.5306
AJAP1 adherens junctions associated protein 1 0.486425
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.4215
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.403461
TRIB2 tribbles pseudokinase 2 0.403461
EDNRA endothelin receptor type A 0.368757
CDKN3 cyclin-dependent kinase inhibitor 3 0.368757
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.345945
EPHX2 epoxide hydrolase 2, cytoplasmic 0.327313
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.311576
ATXN7L1 ataxin 7-like 1 0.297866
WSB1 WD repeat and SOCS box containing 1 0.285417
PROM1 prominin 1 0.264872
ZNF98 zinc finger protein 98 0.256228
LPPR5 lipid phosphate phosphatase-related protein type 5 0.256228
BOC BOC cell adhesion associated, oncogene regulated 0.197766
SIDT1 SID1 transmembrane family, member 1 0.197766
LPAR3 lysophosphatidic acid receptor 3 0.197766
NT5DC1 5'-nucleotidase domain containing 1 0.197766
PHTF2 putative homeodomain transcription factor 2 0.197766
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 0.197766
LZTS1 leucine zipper, putative tumor suppressor 1 0.197766
ELF4 E74-like factor 4 (ets domain transcription factor) 0.15771
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.15771
PCDH9 protocadherin 9 0.15771
SGK1 serum/glucocorticoid regulated kinase 1 0.15771
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.15771
NFASC neurofascin 0.15771
EXOC2 exocyst complex component 2 0.15771
DYM dymeclin 0.126165
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.126165
FZD1 frizzled class receptor 1 0.126165
ANKRD12 ankyrin repeat domain 12 0.126165
IL17D interleukin 17D 0.126165
ABRA actin binding Rho activating protein 0.126165
KRT8P11 keratin 8 pseudogene 11 0.100789
MAP3K7CL MAP3K7 C-terminal like 0.100789
WWOX WW domain containing oxidoreductase 0.100789
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.100789
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 0.100789
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.100789
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.064973
MYO16 myosin XVI 0.064973
ZNF804B zinc finger protein 804B 0.064973
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.052255
MPPED2 metallophosphoesterase domain containing 2 0.052255
MTMR4 myotubularin related protein 4 0.052255
ISL1 ISL LIM homeobox 1 0.043246
LIN7A lin-7 homolog A (C. elegans) 0.043246