dental caries Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp. The three most prominent theories used to explain the etiology of the disease are that acids produced by bacteria lead to decalcification; that micro-organisms destroy the enamel protein; or that keratolytic micro-organisms produce chelates that lead to decalcification. (Experimental Factor Ontology, EFO_0003819)
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Genes

224 genes co-occuring with the disease dental caries in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DEDD death effector domain containing 2.80718
CD79A CD79a molecule, immunoglobulin-associated alpha 1.72502
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.69269
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1.66195
CSN1S1 casein alpha s1 1.55823
CNOT8 CCR4-NOT transcription complex, subunit 8 1.55203
LPO lactoperoxidase 1.47462
TAS1R2 taste receptor, type 1, member 2 1.46583
LYZL2 lysozyme-like 2 1.41139
ANGPTL6 angiopoietin-like 6 1.32934
IRF6 interferon regulatory factor 6 1.32629
DMBT1 deleted in malignant brain tumors 1 1.31886
LTF lactotransferrin 1.30095
STATH statherin 1.22475
KPNA4 karyopherin alpha 4 (importin alpha 3) 1.14602
OR4M2 olfactory receptor, family 4, subfamily M, member 2 1.1072
LIAS lipoic acid synthetase 1.10343
ANKRD54 ankyrin repeat domain 54 1.07698
AMELX amelogenin, X-linked 1.0669
PROL1 proline rich, lacrimal 1 1.06186
MUC7 mucin 7, secreted 1.02777
GPI glucose-6-phosphate isomerase 1.02018
CST4 cystatin S 0.993174
MTM1 myotubularin 1 0.987271
SSC5D scavenger receptor cysteine rich family, 5 domains 0.982636
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.976323
LYZ lysozyme 0.975903
MPPED2 metallophosphoesterase domain containing 2 0.973801
AMY1B amylase, alpha 1B (salivary) 0.97128
AMY1A amylase, alpha 1A (salivary) 0.97128
AMY1C amylase, alpha 1C (salivary) 0.97128
HTN1 histatin 1 0.953273
ADSL adenylosuccinate lyase 0.945354
AJAP1 adherens junctions associated protein 1 0.93497
GPC2 glypican 2 0.904442
CST1 cystatin SN 0.867549
DSPP dentin sialophosphoprotein 0.841753
CST5 cystatin D 0.840934
TECR trans-2,3-enoyl-CoA reductase 0.796232
DMTF1 cyclin D binding myb-like transcription factor 1 0.783116
AKAP13 A kinase (PRKA) anchor protein 13 0.772887
AMELY amelogenin, Y-linked 0.768801
CALML3 calmodulin-like 3 0.758193
FLNA filamin A, alpha 0.751271
TMLHE trimethyllysine hydroxylase, epsilon 0.747204
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.708364
MGAM maltase-glucoamylase 0.696306
GFER growth factor, augmenter of liver regeneration 0.6939
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.686291
WDR20 WD repeat domain 20 0.685091
MAN2A1 mannosidase, alpha, class 2A, member 1 0.681495
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.675112
TWSG1 twisted gastrulation BMP signaling modulator 1 0.65565
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.650508
IGHV3-30 immunoglobulin heavy variable 3-30 0.644586
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.640251
GDF11 growth differentiation factor 11 0.63042
RHOU ras homolog family member U 0.622967
BCORL1 BCL6 corepressor-like 1 0.618268
ALPL alkaline phosphatase, liver/bone/kidney 0.615529
TUFT1 tuftelin 1 0.58939
LMBRD1 LMBR1 domain containing 1 0.588612
ALPPL2 alkaline phosphatase, placental-like 2 0.587054
ALPP alkaline phosphatase, placental 0.586665
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.586665
TLR2 toll-like receptor 2 0.582773
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 0.559839
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.541992
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.540829
RPL7 ribosomal protein L7 0.525746
WARS tryptophanyl-tRNA synthetase 0.51842
CA6 carbonic anhydrase VI 0.514186
HBA2 hemoglobin, alpha 2 0.505356
TMEM54 transmembrane protein 54 0.500761
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.497321
HEBP1 heme binding protein 1 0.496175
FXYD1 FXYD domain containing ion transport regulator 1 0.494266
ENAM enamelin 0.493885
EDARADD EDAR-associated death domain 0.490454
LEFTY1 left-right determination factor 1 0.490072
EED embryonic ectoderm development 0.489311
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.487027
TSPO translocator protein (18kDa) 0.485125
TAS2R38 taste receptor, type 2, member 38 0.484744
KLK4 kallikrein-related peptidase 4 0.482844
SRL sarcalumenin 0.482844
CROCC ciliary rootlet coiled-coil, rootletin 0.480566
DES desmin 0.477151
DEFA3 defensin, alpha 3, neutrophil-specific 0.476772
JMJD6 jumonji domain containing 6 0.474877
DNAH8 dynein, axonemal, heavy chain 8 0.460883
DEFA1B defensin, alpha 1B 0.460129
DEFA1 defensin, alpha 1 0.460129
DEFB1 defensin, beta 1 0.453339
TFIP11 tuftelin interacting protein 11 0.452962
ACTN2 actinin, alpha 2 0.449571
DTNA dystrobrevin, alpha 0.448064
CAMP cathelicidin antimicrobial peptide 0.447687
MARCO macrophage receptor with collagenous structure 0.438658
PRRC2A proline-rich coiled-coil 2A 0.42664
FGF10 fibroblast growth factor 10 0.425514
DEFB103A defensin, beta 103A 0.424765
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.424765
GZMK granzyme K (granzyme 3; tryptase II) 0.42364
DSTN destrin (actin depolymerizing factor) 0.421765
CD4 CD4 molecule 0.421016
ALB albumin 0.416896
POU2F1 POU class 2 homeobox 1 0.416521
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.415398
ESRRB estrogen-related receptor beta 0.409787
PEPD peptidase D 0.40904
NKX2-3 NK2 homeobox 3 0.398216
FAIM2 Fas apoptotic inhibitory molecule 2 0.397843
MAEA macrophage erythroblast attacher 0.397471
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.397098
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.389281
DEFB103B defensin, beta 103B 0.386308
LRRC38 leucine rich repeat containing 38 0.383708
FN1 fibronectin 1 0.379256
MMP9 matrix metallopeptidase 9 0.376661
NARS asparaginyl-tRNA synthetase 0.370737
SMS spermine synthase 0.359289
ALDOC aldolase C, fructose-bisphosphate 0.357077
GLO1 glyoxalase I 0.349717
LACTB lactamase, beta 0.343473
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.337975
MLF1 myeloid leukemia factor 1 0.33651
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.335046
INHBA inhibin, beta A 0.32993
INS insulin 0.328105
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 0.321909
SOCS5 suppressor of cytokine signaling 5 0.315366
BPIFA1 BPI fold containing family A, member 1 0.314278
IFT88 intraflagellar transport 88 0.314278
SPA17 sperm autoantigenic protein 17 0.304503
GRIK4 glutamate receptor, ionotropic, kainate 4 0.304142
MMP20 matrix metallopeptidase 20 0.302337
CA10 carbonic anhydrase X 0.298011
HRC histidine rich calcium binding protein 0.296931
WRAP73 WD repeat containing, antisense to TP73 0.292257
BSN bassoon presynaptic cytomatrix protein 0.285802
MMD monocyte to macrophage differentiation-associated 0.272953
DKKL1 dickkopf-like 1 0.27153
TMEM51 transmembrane protein 51 0.270819
DCT dopachrome tautomerase 0.270108
POU2AF1 POU class 2 associating factor 1 0.270108
RRM1 ribonucleotide reductase M1 0.268687
USP9X ubiquitin specific peptidase 9, X-linked 0.266913
ICT1 immature colon carcinoma transcript 1 0.266558
ALDOB aldolase B, fructose-bisphosphate 0.264431
GPC1 glypican 1 0.264431
UST uronyl-2-sulfotransferase 0.260891
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.260538
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.24715
DCXR dicarbonyl/L-xylulose reductase 0.235964
CAT catalase 0.235268
TLR4 toll-like receptor 4 0.233878
EPHA7 EPH receptor A7 0.233878
CSN2 casein beta 0.230755
HSPG2 heparan sulfate proteoglycan 2 0.229024
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.228333
NADK NAD kinase 0.22145
BCOR BCL6 corepressor 0.220081
ATAD3A ATPase family, AAA domain containing 3A 0.21974
LARS leucyl-tRNA synthetase 0.21974
FLAD1 flavin adenine dinucleotide synthetase 1 0.215314
ARHGAP1 Rho GTPase activating protein 1 0.213959
NPS neuropeptide S 0.211597
FANCB Fanconi anemia, complementation group B 0.210925
ALDOA aldolase A, fructose-bisphosphate 0.210925
FST follistatin 0.208914
SIX2 SIX homeobox 2 0.208579
FGF7 fibroblast growth factor 7 0.207245
KIF5B kinesin family member 5B 0.200331
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.199356
MASP2 mannan-binding lectin serine peptidase 2 0.198064
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.195501
SAT1 spermidine/spermine N1-acetyltransferase 1 0.188938
CHD1L chromodomain helicase DNA binding protein 1-like 0.184424
MMP2 matrix metallopeptidase 2 0.184424
RCAN1 regulator of calcineurin 1 0.183248
PRDM16 PR domain containing 16 0.182086
FZD1 frizzled class receptor 1 0.181798
DCD dermcidin 0.180937
PTK2B protein tyrosine kinase 2 beta 0.180937
FAT1 FAT atypical cadherin 1 0.180652
AZU1 azurocidin 1 0.178403
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.177301
ECI1 enoyl-CoA delta isomerase 1 0.176485
NIPBL Nipped-B homolog (Drosophila) 0.174354
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 0.173832
NPEPPS aminopeptidase puromycin sensitive 0.172544
YME1L1 YME1-like 1 ATPase 0.170789
LUM lumican 0.170054
NAGA N-acetylgalactosaminidase, alpha- 0.169812
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.168381
KMT2A lysine (K)-specific methyltransferase 2A 0.164571
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.164149
ERAS ES cell expressed Ras 0.163729
SRPX2 sushi-repeat containing protein, X-linked 2 0.162505
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.160761
CLDN16 claudin 16 0.160021
HAX1 HCLS1 associated protein X-1 0.15948
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.158951
CLEC4C C-type lectin domain family 4, member C 0.144496
PC pyruvate carboxylase 0.143552
AURKA aurora kinase A 0.143487
CXCL2 chemokine (C-X-C motif) ligand 2 0.143265
BGN biglycan 0.143026
COX5A cytochrome c oxidase subunit Va 0.142948
DCN decorin 0.141943
LAX1 lymphocyte transmembrane adaptor 1 0.141871
LY96 lymphocyte antigen 96 0.141223
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.141085
GNAS GNAS complex locus 0.140996
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.140629
MCM8 minichromosome maintenance complex component 8 0.140364
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.139915
NOD2 nucleotide-binding oligomerization domain containing 2 0.1399
MPZ myelin protein zero 0.139577
MMP3 matrix metallopeptidase 3 0.136235
CXCL10 chemokine (C-X-C motif) ligand 10 0.135778
ALK anaplastic lymphoma receptor tyrosine kinase 0.134126
CTSB cathepsin B 0.12972