dental caries Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp. The three most prominent theories used to explain the etiology of the disease are that acids produced by bacteria lead to decalcification; that micro-organisms destroy the enamel protein; or that keratolytic micro-organisms produce chelates that lead to decalcification. (Experimental Factor Ontology, EFO_0003819)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:216
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Genes

55 genes associated with the disease dental caries in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
LYZL2 lysozyme-like 2 1.42967
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.33186
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 1.31635
CDKN3 cyclin-dependent kinase inhibitor 3 1.28906
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 1.28906
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 1.28906
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 1.26953
ATXN7L1 ataxin 7-like 1 1.23034
PROM1 prominin 1 1.20161
MPPED2 metallophosphoesterase domain containing 2 1.19685
AAMP angio-associated, migratory cell protein 1.14463
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 1.14463
LPPR5 lipid phosphate phosphatase-related protein type 5 1.14463
NT5DC1 5'-nucleotidase domain containing 1 1.14463
BOC BOC cell adhesion associated, oncogene regulated 1.14463
SIDT1 SID1 transmembrane family, member 1 1.14463
PCDH9 protocadherin 9 1.10764
EXOC2 exocyst complex component 2 1.10764
RTEL1 regulator of telomere elongation helicase 1 1.10764
ELF4 E74-like factor 4 (ets domain transcription factor) 1.10764
FRMD4A FERM domain containing 4A 1.08966
IL17D interleukin 17D 1.07599
DYM dymeclin 1.07599
CTNNA3 catenin (cadherin-associated protein), alpha 3 1.07599
FHIT fragile histidine triad 1.04846
MAP3K7CL MAP3K7 C-terminal like 1.04846
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 1.04846
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 1.04846
TEX14 testis expressed 14 1.03788
LOC100132731 uncharacterized LOC100132731 1.02476
OPCML opioid binding protein/cell adhesion molecule-like 1.02476
SCN9A sodium channel, voltage gated, type IX alpha subunit 1.00407
PVALB parvalbumin 1.00407
MYO16 myosin XVI 1.00407
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.995478
RAD51C RAD51 paralog C 0.994762
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.986376
MTMR4 myotubularin related protein 4 0.986376
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.986376
RNF43 ring finger protein 43 0.86494
TMC3 transmembrane channel-like 3 0.824363
PLLP plasmolipin 0.802617
HDAC4 histone deacetylase 4 0.714351
MVB12B multivesicular body subunit 12B 0.712564
TRIM37 tripartite motif containing 37 0.70946
MYO5B myosin VB 0.665868
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 0.658446
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 0.637975
GPR39 G protein-coupled receptor 39 0.62609
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.612695
HSF5 heat shock transcription factor family member 5 0.588054
PLS1 plastin 1 0.57981
RAB3C RAB3C, member RAS oncogene family 0.57934
WWC3 WWC family member 3 0.55831
EML1 echinoderm microtubule associated protein like 1 0.539419