depression Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Form of depression in those MIDDLE AGE with feelings of ANXIETY.|An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.|Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.|Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.|Severe mental disorder with onset in MIDDLE AGE, marked by withdrawl, abnormal affect, disturbed intellectual processes, and there may be regression. (Experimental Factor Ontology, EFO_0003761)
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Genes

249 genes co-occuring with the biological term depression in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADAR adenosine deaminase, RNA-specific
ADCY5 adenylate cyclase 5
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADORA2A adenosine A2a receptor
ADRA2A adrenoceptor alpha 2A
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRBK1 adrenergic, beta, receptor kinase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKR1C4 aldo-keto reductase family 1, member C4
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKTIP AKT interacting protein
ANKK1 ankyrin repeat and kinase domain containing 1
ANXA2 annexin A2
APC adenomatous polyposis coli
APOA4 apolipoprotein A-IV
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARRB1 arrestin, beta 1
ASMT acetylserotonin O-methyltransferase
ATF2 activating transcription factor 2
AVP arginine vasopressin
AVPR1B arginine vasopressin receptor 1B
BDNF brain-derived neurotrophic factor
BSN bassoon presynaptic cytomatrix protein
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAT choline O-acetyltransferase
CHGA chromogranin A
CHRM2 cholinergic receptor, muscarinic 2
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CNTNAP2 contactin associated protein-like 2
COMT catechol-O-methyltransferase
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CRY2 cryptochrome circadian clock 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAO D-amino-acid oxidase
DAOA D-amino acid oxidase activator
DCANP1 dendritic cell-associated nuclear protein
DGKH diacylglycerol kinase, eta
DIO1 deiodinase, iodothyronine, type I
DISC1 disrupted in schizophrenia 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP4 dipeptidyl-peptidase 4
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
DTNBP1 dystrobrevin binding protein 1
EGF epidermal growth factor
ENO2 enolase 2 (gamma, neuronal)
FABP2 fatty acid binding protein 2, intestinal
FKBP5 FK506 binding protein 5
FMR1 fragile X mental retardation 1
FOXP2 forkhead box P2
FTO fat mass and obesity associated
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GALR1 galanin receptor 1
GALR2 galanin receptor 2
GALR3 galanin receptor 3
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDNF glial cell derived neurotrophic factor
GFAP glial fibrillary acidic protein
GHRL ghrelin/obestatin prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLS2 glutaminase 2 (liver, mitochondrial)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPR39 G protein-coupled receptor 39
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GPX1 glutathione peroxidase 1
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRID2 glutamate receptor, ionotropic, delta 2
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM7 glutamate receptor, metabotropic 7
GSK3B glycogen synthase kinase 3 beta
HES6 hes family bHLH transcription factor 6
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMCN1 hemicentin 1
HOMER1 homer scaffolding protein 1
HP1BP3 heterochromatin protein 1, binding protein 3
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA4 heat shock 70kDa protein 4
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNA1 interferon, alpha 1
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IGF2R insulin-like growth factor 2 receptor
IL10 interleukin 10
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL4 interleukin 4
IL6 interleukin 6
IRF1 interferon regulatory factor 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
L1CAM L1 cell adhesion molecule
LEP leptin
LEPQTL1 Leptin, serum levels of
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRRK2 leucine-rich repeat kinase 2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAP1B microtubule-associated protein 1B
MAP2K1 mitogen-activated protein kinase kinase 1
MAPT microtubule-associated protein tau
MCPH1 microcephalin 1
MIR1202 microRNA 1202
MIR132 microRNA 132
MIR182 microRNA 182
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1A melatonin receptor 1A
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NCAM1 neural cell adhesion molecule 1
NF1 neurofibromin 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOTCH3 notch 3
NPAS2 neuronal PAS domain protein 2
NPPB natriuretic peptide B
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRG1 neuregulin 1
NRXN1 neurexin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
OPRM1 opioid receptor, mu 1
OR7D4 olfactory receptor, family 7, subfamily D, member 4
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARK2 parkin RBR E3 ubiquitin protein ligase
PAWR PRKC, apoptosis, WT1, regulator
PCLO piccolo presynaptic cytomatrix protein
PDE11A phosphodiesterase 11A
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE4A phosphodiesterase 4A, cAMP-specific
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PF4 platelet factor 4
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POLG polymerase (DNA directed), gamma
POMC proopiomelanocortin
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRL prolactin
PRNP prion protein
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYY peptide YY
RAI1 retinoic acid induced 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RNF123 ring finger protein 123
RTN4 reticulon 4
S100B S100 calcium binding protein B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SIRT2 sirtuin 2
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
STAT1 signal transducer and activator of transcription 1, 91kDa
STAU2 staufen double-stranded RNA binding protein 2
STX1A syntaxin 1A (brain)
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SYN1 synapsin I
TACR1 tachykinin receptor 1
TEF thyrotrophic embryonic factor
TGFBR3 transforming growth factor, beta receptor III
TIMELESS timeless circadian clock
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TOR1A torsin family 1, member A (torsin A)
TP53 tumor protein p53
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPO translocator protein (18kDa)
TTC9B tetratricopeptide repeat domain 9B
TTR transthyretin
VEGFA vascular endothelial growth factor A
WFS1 Wolfram syndrome 1 (wolframin)