depression Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure. (Human Phenotype Ontology, HP_0000716)
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Genes

146 genes associated with the disease depression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOE apolipoprotein E
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASMT acetylserotonin O-methyltransferase
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATXN3 ataxin 3
AXIN2 axin 2
BDNF brain-derived neurotrophic factor
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BICC1 BicC family RNA binding protein 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CDH13 cadherin 13
CDH17 cadherin 17, LI cadherin (liver-intestine)
CHAT choline O-acetyltransferase
CHRM2 cholinergic receptor, muscarinic 2
CLASP2 cytoplasmic linker associated protein 2
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CRP C-reactive protein, pentraxin-related
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSNK1E casein kinase 1, epsilon
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAOA D-amino acid oxidase activator
DBP D site of albumin promoter (albumin D-box) binding protein
DISC1 disrupted in schizophrenia 1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DTNBP1 dystrobrevin binding protein 1
DVL2 dishevelled segment polarity protein 2
EIF3F eukaryotic translation initiation factor 3, subunit F
EMX2 empty spiracles homeobox 2
EPHB1 EPH receptor B1
FKBP5 FK506 binding protein 5
FZD3 frizzled class receptor 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GHRL ghrelin/obestatin prepropeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
KCNK2 potassium channel, two pore domain subfamily K, member 2
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MCTP2 multiple C2 domains, transmembrane 2
MIR30E microRNA 30e
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYO3A myosin IIIA
MYT1L myelin transcription factor 1-like
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIL3 nuclear factor, interleukin 3 regulated
NLGN1 neuroligin 1
NPAS2 neuronal PAS domain protein 2
NPY neuropeptide Y
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PDE11A phosphodiesterase 11A
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE9A phosphodiesterase 9A
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCH protein kinase C, eta
PSEN1 presenilin 1
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RGMA repulsive guidance molecule family member a
RHCG Rh family, C glycoprotein
RORA RAR-related orphan receptor A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SLFN12L schlafen family member 12-like
SOD2 superoxide dismutase 2, mitochondrial
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SV2B synaptic vesicle glycoprotein 2B
TBX21 T-box 21
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
TIMELESS timeless circadian clock
TNF tumor necrosis factor
TP53 tumor protein p53
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TSC2 tuberous sclerosis 2
TSNAX translin-associated factor X
UCN3 urocortin 3
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WNT7A wingless-type MMTV integration site family, member 7A
XBP1 X-box binding protein 1
ZEB2 zinc finger E-box binding homeobox 2